N¹-((2,5-dimethyloxazol-4-yl)methyl)-N³-((2S,3R)-3-hydroxy-4-((N-isobutyl-4-methoxyphenyl)sulfonamido)-1-phenylbutan-2-yl)-N¹-methyl-5-(methylamino)isophthalamide

Base Information

• Chemical Name: N¹-((2,5-dimethyloxazol-4-yl)methyl)-N³-((2S,3R)-3-hydroxy-4-((N-isobutyl-4-methoxyphenyl)sulfonamido)-1-phenylbutan-2-yl)-N¹-methyl-5-(methylamino)isophthalamide
• CAS No.: 1203560-50-2
• Molecular Formula: C₃₇H₄₇N₅O₇S
• Molecular Weight: 705.875

Synonyms:N¹-((2,5-dimethyloxazol-4-yl)methyl)-N³-((2S,3R)-3-hydroxy-4-((N-isobutyl-4-methoxyphenyl)sulfonamido)-1-phenylbutan-2-yl)-N¹-methyl-5-(methylamino)isophthalamide

Chemical Property of N¹-((2,5-dimethyloxazol-4-yl)methyl)-N³-((2S,3R)-3-hydroxy-4-((N-isobutyl-4-methoxyphenyl)sulfonamido)-1-phenylbutan-2-yl)-N¹-methyl-5-(methylamino)isophthalamide

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Technology Process of N¹-((2,5-dimethyloxazol-4-yl)methyl)-N³-((2S,3R)-3-hydroxy-4-((N-isobutyl-4-methoxyphenyl)sulfonamido)-1-phenylbutan-2-yl)-N¹-methyl-5-(methylamino)isophthalamide

There total 5 articles about N¹-((2,5-dimethyloxazol-4-yl)methyl)-N³-((2S,3R)-3-hydroxy-4-((N-isobutyl-4-methoxyphenyl)sulfonamido)-1-phenylbutan-2-yl)-N¹-methyl-5-(methylamino)isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-((tert-butoxycarbonyl)(methyl)amino)-5-(((2,5-dimethyloxazol-4-yl)methyl)(methyl)carbamoyl)benzoic acid + N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-methoxybenzenesulfonamide (159005-71-7) → N1-((2,5-dimethyloxazol-4-yl)methyl)-N3-((2S,3R)-3-hydroxy-4-((N-isobutyl-4-methoxyphenyl)sulfonamido)-1-phenylbutan-2-yl)-N1-methyl-5-(methylamino)isophthalamide (1203560-50-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1016/j.bmc.2017.04.005

Reference yield:

2,5-dimethyloxazol-4-ylmethanamine (859850-62-7) → N1-((2,5-dimethyloxazol-4-yl)methyl)-N3-((2S,3R)-3-hydroxy-4-((N-isobutyl-4-methoxyphenyl)sulfonamido)-1-phenylbutan-2-yl)-N1-methyl-5-(methylamino)isophthalamide (1203560-50-2)

Guidance literature:

Multi-step reaction with 4 steps

1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 25 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 25 °C

3: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 16 h / 0 - 25 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 25 °C

With lithium hydroxide monohydrate; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; mineral oil;

DOI:10.1016/j.bmc.2017.04.005

Reference yield:

C15H19NO6 → N1-((2,5-dimethyloxazol-4-yl)methyl)-N3-((2S,3R)-3-hydroxy-4-((N-isobutyl-4-methoxyphenyl)sulfonamido)-1-phenylbutan-2-yl)-N1-methyl-5-(methylamino)isophthalamide (1203560-50-2)

Guidance literature:

Multi-step reaction with 4 steps

1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 25 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 25 °C

3: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 16 h / 0 - 25 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 25 °C

With lithium hydroxide monohydrate; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; mineral oil;

DOI:10.1016/j.bmc.2017.04.005

upstream raw materials:

2,5-dimethyloxazol-4-ylmethanamine

N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-methoxybenzenesulfonamide

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