methyl 3-p-hydroxyphenyl-2-t-butyldimethylsiloxy propionate

Base Information

• Chemical Name: methyl 3-p-hydroxyphenyl-2-t-butyldimethylsiloxy propionate
• CAS No.: 481072-51-9
• Molecular Formula: C₁₆H₂₆O₄Si
• Molecular Weight: 310.466
• Mol file: 481072-51-9.mol

Synonyms:methyl 3-p-hydroxyphenyl-2-t-butyldimethylsiloxy propionate

Chemical Property of methyl 3-p-hydroxyphenyl-2-t-butyldimethylsiloxy propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-p-hydroxyphenyl-2-t-butyldimethylsiloxy propionate

There total 2 articles about methyl 3-p-hydroxyphenyl-2-t-butyldimethylsiloxy propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 3-p-benzyloxyphenyl-2-t-butyldimethylsiloxy propionate (481072-85-9) → methyl 3-p-hydroxyphenyl-2-t-butyldimethylsiloxy propionate (481072-51-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate;

DOI:10.1016/j.tet.2005.06.022

Reference yield:

(+/-)-methyl 3-p-benzyloxyphenyl-2-hydroxypropionate (128316-64-3,481072-37-1) → methyl 3-p-hydroxyphenyl-2-t-butyldimethylsiloxy propionate (481072-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / imidazole; 4-(dimethylamino)pyridine / dimethylformamide

2: 87 percent / hydrogen / Pd/C / ethyl acetate

With 1H-imidazole; dmap; hydrogen; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2005.06.022

Reference yield: 88.0%

methyl 3-p-hydroxyphenyl-2-t-butyldimethylsiloxy propionate (481072-51-9) + acetic anhydride (108-24-7) → methyl 3-p-acetoxyphenyl-2-t-butyldimethylsiloxy propionate (864070-64-4)

Guidance literature:

With pyridine;

DOI:10.1016/j.tet.2005.06.022

upstream raw materials:

methyl 3-p-benzyloxyphenyl-2-t-butyldimethylsiloxy propionate

(+/-)-methyl 3-p-benzyloxyphenyl-2-hydroxypropionate

Downstream raw materials:

methyl 3-p-acetoxyphenyl-2-t-butyldimethylsiloxy propionate

(Z)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-2-[(2S,3R,4S,5S,6S)-3,4,5-tris-(tert-butyl-dimethyl-silanyloxy)-6-formyl-tetrahydro-pyran-2-yloxy]-acrylic acid methyl ester

methyl (Z)-2-(2',3',4'-tri-O-t-butyldimethylsilyl-β-D-galactopyranosyloxy)-3-p-t-butyldimethylsiloxyphenyl acrylate

methyl (Z)-2-(6'-O-acetyl-2',3',4'-tri-O-t-butyldimethylsilyl-β-D-galactopyranosyloxy)-3-p-t-butyldimethylsiloxyphenyl acrylate