5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

Base Information

• Chemical Name: 5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine
• CAS No.: 112141-39-6
• Molecular Formula: C₃₉H₃₆N₆O₉
• Molecular Weight: 732.75
• Mol file: 112141-39-6.mol

Synonyms:5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

Chemical Property of 5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

There total 4 articles about 5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>adenosine (111275-31-1) → 5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (112141-39-6)

Guidance literature:

With acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 1.5h; Ambient temperature;

DOI:10.1002/hlca.19950780706

Reference yield: 90.0%

N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (88121-73-7) + mono-4-methoxytrityl chloride (14470-28-1) → 5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (112141-39-6)

Guidance literature:

With pyridine; for 18h; Ambient temperature;

DOI:10.1002/hlca.19930760122

Reference yield:

1-methyl-3-[2-(4-nitrophenyl)ethoxycarbonyl]imidazolium chloride (88091-70-7) → 5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (112141-39-6)

Guidance literature:

Multi-step reaction with 2 steps

2: 90 percent / pyridine / 18 h / Ambient temperature

With pyridine;

DOI:10.1002/hlca.19930760122

upstream raw materials:

N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

mono-4-methoxytrityl chloride

5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>adenosine

1-methyl-3-[2-(4-nitrophenyl)ethoxycarbonyl]imidazolium chloride

Downstream raw materials:

5'-O-(p-methoxyphenyldiphenylmethyl)adenosine

5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>adenosine

3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

2'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine