2-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclo hexyloxy)-5-ethylpyrimidine

Base Information

Chemical Name:2-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclo hexyloxy)-5-ethylpyrimidine
CAS No.:1361392-06-4
Molecular Formula:C₂₅H₂₆F₂N₂O₄S
Molecular Weight:488.555
Hs Code.:

Synonyms:2-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclo hexyloxy)-5-ethylpyrimidine

Suppliers and Price of 2-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclo hexyloxy)-5-ethylpyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclo hexyloxy)-5-ethylpyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclo hexyloxy)-5-ethylpyrimidine

There total 6 articles about 2-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclo hexyloxy)-5-ethylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1361391-82-3
2-(4-(4-bromo-2,6-difluorophenoxy)cyclohexyloxy)-5-ethylpyrimidine

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 1361392-06-4
2-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclo hexyloxy)-5-ethylpyrimidine

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; at 180 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 1361391-19-6
4-(5-ethylpyrimidin-2-yloxy)cyclohexanol

: 1361392-06-4
2-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclo hexyloxy)-5-ethylpyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 15 h / 90 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 0.17 h / 180 °C / Microwave irradiation

With sodium carbonate; caesium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 556-48-9
1,4-Cyclohexanediol

: 1361392-06-4
2-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclo hexyloxy)-5-ethylpyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

1.2: 16 h / 70 °C

2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 90 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 0.17 h / 180 °C / Microwave irradiation

With sodium hydride; sodium carbonate; caesium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;