N-(cyano(d₂-methyl))-4-(2-(4-(morpholinophenyl)amino)pyrimidin-4-yl)benzamide

Base Information

Chemical Name:N-(cyano(d₂-methyl))-4-(2-(4-(morpholinophenyl)amino)pyrimidin-4-yl)benzamide
CAS No.:1619927-63-7
Molecular Formula:C₂₃H₂₂N₆O₂
Molecular Weight:416.451
Hs Code.:

N-(cyano(d<SUB>2</SUB>-methyl))-4-(2-(4-(morpholinophenyl)amino)pyrimidin-4-yl)benzamide

Synonyms:N-(cyano(d₂-methyl))-4-(2-(4-(morpholinophenyl)amino)pyrimidin-4-yl)benzamide

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Chemical Property of N-(cyano(d₂-methyl))-4-(2-(4-(morpholinophenyl)amino)pyrimidin-4-yl)benzamide

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Technology Process of N-(cyano(d₂-methyl))-4-(2-(4-(morpholinophenyl)amino)pyrimidin-4-yl)benzamide

There total 7 articles about N-(cyano(d₂-methyl))-4-(2-(4-(morpholinophenyl)amino)pyrimidin-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 945749-71-3
4-(2-(4-(morpholinophenyl)amino)pyrimidin-4-yl)benzoic acid

: 2-amino-2,2-d₂-acetonitrile hydrochloride

: 1619927-63-7
N-(cyano(d₂-methyl))-4-(2-(4-(morpholinophenyl)amino)pyrimidin-4-yl)benzamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere;

Reference yield:

: 10389-51-2
1-morpholino-4-nitrobenzene

: 1619927-63-7
N-(cyano(d₂-methyl))-4-(2-(4-(morpholinophenyl)amino)pyrimidin-4-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 18 h / 40 °C

2: toluene-4-sulfonic acid / water; 1,4-dioxane / 20 h / Reflux

3: water; sodium hydroxide / tetrahydrofuran; methanol / 2 h / 65 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; water; hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 2524-67-6,86759-37-7
4-morpholino-4-yl-phenylamine

: 1619927-63-7
N-(cyano(d₂-methyl))-4-(2-(4-(morpholinophenyl)amino)pyrimidin-4-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / water; 1,4-dioxane / 20 h / Reflux

2: water; sodium hydroxide / tetrahydrofuran; methanol / 2 h / 65 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

With water; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;