2-<3-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)propyl>-2-(4-fluorophenyl)-1,3-dithiolane

Base Information

• Chemical Name: 2-<3-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)propyl>-2-(4-fluorophenyl)-1,3-dithiolane
• CAS No.: 153075-92-4
• Molecular Formula: C₁₉H₂₆FNO₂S₂
• Molecular Weight: 383.551
• Mol file: 153075-92-4.mol

Synonyms:2-<3-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)propyl>-2-(4-fluorophenyl)-1,3-dithiolane

Chemical Property of 2-<3-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)propyl>-2-(4-fluorophenyl)-1,3-dithiolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<3-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)propyl>-2-(4-fluorophenyl)-1,3-dithiolane

There total 3 articles about 2-<3-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)propyl>-2-(4-fluorophenyl)-1,3-dithiolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.6%

4-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)-4'-fluorobutyrophenone (51787-84-9) + ethane-1,2-dithiol (540-63-6) → 2-<3-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)propyl>-2-(4-fluorophenyl)-1,3-dithiolane (153075-92-4)

Guidance literature:

boron trifluoride diethyl etherate; In methanol; for 2h; Ambient temperature;

DOI:10.1055/s-1993-25946

Reference yield:

4,4-ethylenedioxy-piperidine (177-11-7) → 2-<3-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)propyl>-2-(4-fluorophenyl)-1,3-dithiolane (153075-92-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / K₂CO₃, KI / dimethylformamide / 16 h / Heating

2: 84.6 percent / BF₃*Et₂O / methanol / 2 h / Ambient temperature

With potassium carbonate; potassium iodide; boron trifluoride diethyl etherate; In methanol; N,N-dimethyl-formamide;

DOI:10.1055/s-1993-25946

Reference yield:

4-(4-fluorophenyl)-4-oxo-n-butyl chloride (3874-54-2,41167-07-1) → 2-<3-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)propyl>-2-(4-fluorophenyl)-1,3-dithiolane (153075-92-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / K₂CO₃, KI / dimethylformamide / 16 h / Heating

2: 84.6 percent / BF₃*Et₂O / methanol / 2 h / Ambient temperature

With potassium carbonate; potassium iodide; boron trifluoride diethyl etherate; In methanol; N,N-dimethyl-formamide;

DOI:10.1055/s-1993-25946

upstream raw materials:

4-(1,4-dioxa-8-azaspiro<4.5>dec-8-yl)-4'-fluorobutyrophenone

ethane-1,2-dithiol

4,4-ethylenedioxy-piperidine

4-(4-fluorophenyl)-4-oxo-n-butyl chloride

Downstream raw materials:

1-<4,4-ethylenedithio-4-(4-fluorophenyl)butyl>-4-piperidinone