1-bromo-4-2-butanone

Base Information

• Chemical Name: 1-bromo-4-2-butanone
• CAS No.: 72155-10-3
• Molecular Formula: C₁₂H₁₃BrO₄
• Molecular Weight: 301.137
• Mol file: 72155-10-3.mol

Synonyms:1-bromo-4-2-butanone

Chemical Property of 1-bromo-4-2-butanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-bromo-4-2-butanone

There total 4 articles about 1-bromo-4-2-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-propionic acid (72155-09-0) → 1-bromo-4-2-butanone (72155-10-3)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride / dichloromethane / 1 h / Reflux

2: diethyl ether / 1.67 h / Cooling with ice

3: hydrogen bromide / water; diethyl ether / 1.5 h / Reflux

With oxalyl dichloride; hydrogen bromide; In diethyl ether; dichloromethane; water;

DOI:10.1021/acs.jmedchem.6b00594

Reference yield:

4-(2-Chlorocarbonyl-ethoxy)-benzoic acid methyl ester → 1-bromo-4-2-butanone (72155-10-3)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 1.67 h / Cooling with ice

2: hydrogen bromide / water; diethyl ether / 1.5 h / Reflux

With hydrogen bromide; In diethyl ether; water;

DOI:10.1021/acs.jmedchem.6b00594

Reference yield:

C12H14O4 → 1-bromo-4-2-butanone (72155-10-3)

Guidance literature:

With hydrogen bromide; In diethyl ether; water; for 1.5h; Reflux;

DOI:10.1021/acs.jmedchem.6b00594

upstream raw materials:

methyl 4-hydroxylbenzoate

3-propionic acid

Downstream raw materials:

1--4-(diethyl N-p-anisoyl-L-glutamate)-2-butanone

1--4--2-butanone

diethyl N--L-glutamate ketal

4-amino-4-deoxy-11-oxahomoaminopterin