2-phenyl-6,7-dihydro-5H-quinazolin-8-one O-[3-(6-(1-((E)-methoxyimino)-ethyl)-pyridin-2-yl)-propyl]-oxime

Base Information

Chemical Name:2-phenyl-6,7-dihydro-5H-quinazolin-8-one O-[3-(6-(1-((E)-methoxyimino)-ethyl)-pyridin-2-yl)-propyl]-oxime
CAS No.:1369586-60-6
Molecular Formula:C₂₅H₂₇N₅O₂
Molecular Weight:429.522
Hs Code.:

Synonyms:2-phenyl-6,7-dihydro-5H-quinazolin-8-one O-[3-(6-(1-((E)-methoxyimino)-ethyl)-pyridin-2-yl)-propyl]-oxime

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Chemical Property of 2-phenyl-6,7-dihydro-5H-quinazolin-8-one O-[3-(6-(1-((E)-methoxyimino)-ethyl)-pyridin-2-yl)-propyl]-oxime

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Technology Process of 2-phenyl-6,7-dihydro-5H-quinazolin-8-one O-[3-(6-(1-((E)-methoxyimino)-ethyl)-pyridin-2-yl)-propyl]-oxime

There total 8 articles about 2-phenyl-6,7-dihydro-5H-quinazolin-8-one O-[3-(6-(1-((E)-methoxyimino)-ethyl)-pyridin-2-yl)-propyl]-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1369588-47-5
(E)-1-[6-(3-aminooxy-propyl)-pyridin-2-yl]-ethanone O-methyl-oxime

: 1369588-54-4
2-phenyl-6,7-dihydro-5H-quinazolin-8-one

: 1369586-60-6
2-phenyl-6,7-dihydro-5H-quinazolin-8-one O-[3-(6-(1-((E)-methoxyimino)-ethyl)-pyridin-2-yl)-propyl]-oxime

Guidance literature:: In methanol; at 20 ℃; for 3h;

Reference yield:

: 1369588-23-7
(E)-1-[6-(3-hydroxy-prop-1-yn-1-yl)-pyridin-2-yl]-ethanone O-methyl-oxime

: 1369586-60-6
2-phenyl-6,7-dihydro-5H-quinazolin-8-one O-[3-(6-(1-((E)-methoxyimino)-ethyl)-pyridin-2-yl)-propyl]-oxime

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3.7 h / 5 - 10 °C

2: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran / 3.5 h

3: hydrazine hydrate / ethanol / 2 h / 20 °C

4: methanol / 3 h / 20 °C

With di-isopropyl azodicarboxylate; hydrogen; hydrazine hydrate; triphenylphosphine; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; ethanol;

Reference yield:

: 49669-13-8
1-(6-bromopyridin-2-yl)-ethanone

: 1369586-60-6
2-phenyl-6,7-dihydro-5H-quinazolin-8-one O-[3-(6-(1-((E)-methoxyimino)-ethyl)-pyridin-2-yl)-propyl]-oxime

Guidance literature:: Multi-step reaction with 6 steps

1: diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 70 °C

2: sodium acetate / methanol / 16 h / 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3.7 h / 5 - 10 °C

4: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran / 3.5 h

5: hydrazine hydrate / ethanol / 2 h / 20 °C

6: methanol / 3 h / 20 °C

With di-isopropyl azodicarboxylate; hydrogen; sodium acetate; hydrazine hydrate; diisopropylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; ethanol;