(2S,3S)-3-Azido-4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butan-1-ol

Base Information

Chemical Name:(2S,3S)-3-Azido-4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butan-1-ol
CAS No.:761408-03-1
Molecular Formula:C₂₈H₃₅N₃O₄Si
Molecular Weight:505.689
Hs Code.:

Synonyms:(2S,3S)-3-Azido-4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butan-1-ol

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Chemical Property of (2S,3S)-3-Azido-4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butan-1-ol

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Technology Process of (2S,3S)-3-Azido-4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butan-1-ol

There total 2 articles about (2S,3S)-3-Azido-4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 761407-83-4
Benzoic acid (2S,3S)-3-azido-4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butyl ester

: 761408-03-1
(2S,3S)-3-Azido-4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butan-1-ol

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 1h;
DOI:10.1021/ol049183a

Reference yield:

: 761408-02-0
Benzoic acid (2S,3S)-3-azido-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-butyl ester

: 761408-03-1
(2S,3S)-3-Azido-4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / NaHCO₃ / La(OTf)3 / toluene / 2 h

2: 81 percent / NaOMe / methanol / 1 h / 20 °C

With sodium methylate; sodium hydrogencarbonate; lanthanum(lll) triflate; In methanol; toluene;
DOI:10.1021/ol049183a

Reference yield: 92.0%

: 761408-03-1
(2S,3S)-3-Azido-4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butan-1-ol

: 761407-84-5
(2S,3S)-3-Azido-4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butyraldehyde

Guidance literature:: (2S,3S)-3-Azido-4-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-butan-1-ol; With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1.5h;

With sodium hydroxide; In diethyl ether; dichloromethane; water; at 20 ℃;
DOI:10.1021/ol049183a