3-methyl-N-(2-methyl-3-pyridyl)-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

Base Information

Chemical Name:3-methyl-N-(2-methyl-3-pyridyl)-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide
CAS No.:1616363-69-9
Molecular Formula:C₂₆H₂₆N₆OS
Molecular Weight:470.598
Hs Code.:

Synonyms:3-methyl-N-(2-methyl-3-pyridyl)-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

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Chemical Property of 3-methyl-N-(2-methyl-3-pyridyl)-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

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Technology Process of 3-methyl-N-(2-methyl-3-pyridyl)-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

There total 6 articles about 3-methyl-N-(2-methyl-3-pyridyl)-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 3430-10-2
2-methyl-3-pyridinamine

: 1616363-73-5
methyl 3-methyl-4-(1-methyl-3-(pyridin-2-yl)-4,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]thiazepin-4-yl)benzoate

: 1616363-69-9
3-methyl-N-(2-methyl-3-pyridyl)-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -60 - 0 ℃; for 0.5h;

Reference yield:

: 1616359-91-1
4-(4-bromo-2-methylphenyl)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

: 1616363-69-9
3-methyl-N-(2-methyl-3-pyridyl)-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene / 1 h / 100 °C / Sealed tube; Microwave irradiation

2: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 - 0 °C

With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hexamethyldisilazane; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl; In tetrahydrofuran;

Reference yield:

: 92406-50-3
1-methyl-3-(pyridin-2-yl)-1H-pyrazol-5-amine

: 1616363-69-9
3-methyl-N-(2-methyl-3-pyridyl)-4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 0.42 h / 150 °C / Sealed tube; Microwave irradiation

2: borane-THF / tetrahydrofuran / 0 - 20 °C

3: tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene / 1 h / 100 °C / Sealed tube; Microwave irradiation

4: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 - 0 °C

With borane-THF; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hexamethyldisilazane; tri tert-butylphosphoniumtetrafluoroborate; molybdenum hexacarbonyl; In tetrahydrofuran; acetonitrile;