1-methylethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate

Base Information

Chemical Name:1-methylethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate
CAS No.:1018816-04-0
Molecular Formula:C₂₆H₃₃F₃N₂O₃
Molecular Weight:478.555
Hs Code.:

Synonyms:1-methylethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate

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Chemical Property of 1-methylethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate

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Technology Process of 1-methylethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate

There total 4 articles about 1-methylethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4′-trifluoromethoxybiphenyl-4-yl)methylammonium chloride

: 1018815-99-0
1-Methylethyl 2-methyl-2-(4-oxo-1-piperidinyl)propanoate

: 1018816-04-0
1-methylethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate

Guidance literature:: (4′-trifluoromethoxybiphenyl-4-yl)methylammonium chloride; 1-Methylethyl 2-methyl-2-(4-oxo-1-piperidinyl)propanoate; With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 18h;

With sodium carbonate; In water; 1,2-dichloro-ethane;

Reference yield:

: 157788-40-4
4'-(trifluoromethoxy)-[1,1'-biphenyl]-4-carbonitrile

: 1018816-04-0
1-methylethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; hydrogen / palladium(II) hydroxide/carbon / ethanol / 1292.9 Torr

2: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 18 h / 20 °C

With hydrogenchloride; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; palladium(II) hydroxide/carbon; In ethanol; 1,2-dichloro-ethane;

Reference yield:

: 51368-55-9
isopropyl 2-bromo-2?methylpropanoate

: 1018816-04-0
1-methylethyl 2-methyl-2-{4-[({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 36 h / Heating / reflux

2: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 18 h / 20 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; In 1,2-dichloro-ethane; acetonitrile;