N-{(1S)-1-[(3R)-1-benzylpyrrolidin-3-yl]ethyl}-N-methylamine

Base Information

• Chemical Name: N-{(1S)-1-[(3R)-1-benzylpyrrolidin-3-yl]ethyl}-N-methylamine
• CAS No.: 161011-00-3
• Molecular Formula: C₁₄H₂₂N₂
• Molecular Weight: 218.342
• Mol file: 161011-00-3.mol

Synonyms:N-{(1S)-1-[(3R)-1-benzylpyrrolidin-3-yl]ethyl}-N-methylamine

Chemical Property of N-{(1S)-1-[(3R)-1-benzylpyrrolidin-3-yl]ethyl}-N-methylamine

Chemical Property:

Purity/Quality:

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Technology Process of N-{(1S)-1-[(3R)-1-benzylpyrrolidin-3-yl]ethyl}-N-methylamine

There total 11 articles about N-{(1S)-1-[(3R)-1-benzylpyrrolidin-3-yl]ethyl}-N-methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

benzyl (1S)-1-[(3S)-1-benzyl-2-oxopyrrolidin-3-yl]ethylcarbamate (161010-99-7) → N-{(1S)-1-[(3R)-1-benzylpyrrolidin-3-yl]ethyl}-N-methylamine (161011-00-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 24h; Heating;

DOI:10.1021/jo0349633

Reference yield: 84.0%

C16H24N2O2 → N-{(1S)-1-[(3R)-1-benzylpyrrolidin-3-yl]ethyl}-N-methylamine (161011-00-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 60h; Inert atmosphere; Reflux;

DOI:10.1021/acs.orglett.6b03397

Reference yield:

(3R,1'R)-1-benzyl-3-[(1'-methanesulfonyloxy)ethyl]pyrrolidine (156765-02-5) → N-{(1S)-1-[(3R)-1-benzylpyrrolidin-3-yl]ethyl}-N-methylamine (161011-00-3)

Guidance literature:

With methylamine; In tetrahydrofuran; water; toluene;

upstream raw materials:

benzyl (1S)-1-[(3S)-1-benzyl-2-oxopyrrolidin-3-yl]ethylcarbamate

methyl (3S)-3-{[(benzyloxy)carbonyl]amino}butanoate

methyl (2S)-2-((1S)-1-{[(benzyloxy)carbonyl]amino}ethyl)pent-4-enoate

(3R,1'R)-1-benzyl-3-[(1'-methanesulfonyloxy)ethyl]pyrrolidine