(4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone tosylate

Base Information

Chemical Name:(4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone tosylate
CAS No.:1307233-50-6
Molecular Formula:C₇H₈O₃S*C₂₂H₂₁N₇O₂
Molecular Weight:587.659
Hs Code.:

Synonyms:(4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone tosylate

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Chemical Property of (4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone tosylate

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Technology Process of (4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone tosylate

There total 8 articles about (4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1307233-44-8
(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone

: 104-15-4
toluene-4-sulfonic acid

: 1307233-50-6
(4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone tosylate

Guidance literature:: In methanol; dichloromethane;

Reference yield:

: 6320-39-4
3-aminopyridin-4-ol

: 1307233-50-6
(4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone tosylate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: triethylamine; triphenylphosphine; hexachloroethane / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

3: N-Bromosuccinimide / acetic acid / 20 °C

4: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 0.67 h / 130 °C / Inert atmosphere; Microwave irradiation

5: dichloromethane; methanol

With N-Bromosuccinimide; hexachloroethane; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; triphenylphosphine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1307233-72-2
3-amino-N-(4-hydroxypyridin-3-yl)pyrazine-2-carboxamide

: 1307233-50-6
(4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone tosylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; triphenylphosphine; hexachloroethane / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

2: N-Bromosuccinimide / acetic acid / 20 °C

3: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 0.67 h / 130 °C / Inert atmosphere; Microwave irradiation

4: dichloromethane; methanol

With N-Bromosuccinimide; hexachloroethane; sodium carbonate; triethylamine; triphenylphosphine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; dichloromethane; acetic acid;