4-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzoic acid ethyl ester

Base Information

Chemical Name:4-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzoic acid ethyl ester
CAS No.:1137486-84-0
Molecular Formula:C₁₇H₁₈N₄O₄
Molecular Weight:342.354
Hs Code.:

Synonyms:4-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzoic acid ethyl ester

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Chemical Property of 4-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzoic acid ethyl ester

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Technology Process of 4-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzoic acid ethyl ester

There total 6 articles about 4-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 58-08-2,138455-22-8,95789-13-2
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

: 5798-75-4
Ethyl 4-bromobenzoate

: 1137486-84-0
4-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzoic acid ethyl ester

Guidance literature:: With potassium phosphate; copper(l) iodide; 1,10-Phenanthroline; In 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide; at 20 - 140 ℃; for 36.1667h; regioselective reaction; Inert atmosphere;

Reference yield: 80.0%

: 51934-41-9
4-iodobenzoic acid ethyl ester

: C₈H₉ClMgN₄O₂

: 1137486-84-0
4-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzoic acid ethyl ester

Guidance literature:: 4-iodobenzoic acid ethyl ester; With TurboGrignard; In tetrahydrofuran; at -40 ℃; for 1h; Inert atmosphere;

With tbepc; In tetrahydrofuran; at -40 - 0 ℃; for 2h; Inert atmosphere;

C₈H₉ClMgN₄O₂; Further stages;
DOI:10.1039/c4cc08494b

Reference yield: 79.0%

: C₁₅H₂₄O₅Ti

: C₈H₉BrMgN₄O₂

: 1137486-84-0
4-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzoic acid ethyl ester

Guidance literature:: C₁₅H₂₄O₅Ti; C₈H₉BrMgN₄O₂; In tetrahydrofuran; at 0 ℃; for 0.666667h; Inert atmosphere;

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; oxygen; cobalt(II) chloride; In tetrahydrofuran; at 0 ℃;
DOI:10.1021/acs.joc.5b01787