ethyl 2-(S)-methyl-2-amino>-3-(4-hydroxyphenyl)propionic acid ester

Base Information

Chemical Name:ethyl 2-(S)-methyl-2-amino>-3-(4-hydroxyphenyl)propionic acid ester
CAS No.:158808-62-9
Molecular Formula:C₂₀H₂₃NO₅
Molecular Weight:357.406
Hs Code.:

ethyl 2-(S)-methyl-2-<N-<(benzyloxy)carbonyl>amino>-3-(4-hydroxyphenyl)propionic acid ester

Synonyms:ethyl 2-(S)-methyl-2-amino>-3-(4-hydroxyphenyl)propionic acid ester

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Chemical Property of ethyl 2-(S)-methyl-2-amino>-3-(4-hydroxyphenyl)propionic acid ester

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Technology Process of ethyl 2-(S)-methyl-2-amino>-3-(4-hydroxyphenyl)propionic acid ester

There total 1 articles about ethyl 2-(S)-methyl-2-amino>-3-(4-hydroxyphenyl)propionic acid ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: ethyl α-methyltyrosine hydrochloride

: 158808-62-9
ethyl 2-(S)-methyl-2-amino>-3-(4-hydroxyphenyl)propionic acid ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; for 72h; Ambient temperature;
DOI:10.1021/jm00042a007

Reference yield:

: 158808-62-9
ethyl 2-(S)-methyl-2-amino>-3-(4-hydroxyphenyl)propionic acid ester

: 158808-64-1
4-{4-[4-((S)-2-Benzyloxycarbonylamino-2-carboxy-propyl)-phenoxy]-butyl}-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 18 h

2: 89 percent / LiOH / tetrahydrofuran; methanol; H₂O / 18 h

With lithium hydroxide; sodium hydride; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm00042a007

Reference yield:

: 158808-62-9
ethyl 2-(S)-methyl-2-amino>-3-(4-hydroxyphenyl)propionic acid ester

: 2-(S)-methyl-2-amino>-3-<4-<<(piperidin-4-yl)butyl>oxy>phenyl>propionic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 18 h

2: 89 percent / LiOH / tetrahydrofuran; methanol; H₂O / 18 h

3: 71 percent / HCl (gas) / ethyl acetate / 1 h / -20 - 0 °C

With hydrogenchloride; lithium hydroxide; sodium hydride; In tetrahydrofuran; methanol; water; ethyl acetate;
DOI:10.1021/jm00042a007