2-bromo-N-(4-((1E,4E)-5-(4-bromophenyl)-3-oxopenta-1,4-dienyl)phenyl)acrylamide

Base Information

Chemical Name:2-bromo-N-(4-((1E,4E)-5-(4-bromophenyl)-3-oxopenta-1,4-dienyl)phenyl)acrylamide
CAS No.:1228557-51-4
Molecular Formula:C₂₀H₁₅Br₂NO₂
Molecular Weight:461.153
Hs Code.:

Synonyms:2-bromo-N-(4-((1E,4E)-5-(4-bromophenyl)-3-oxopenta-1,4-dienyl)phenyl)acrylamide

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Chemical Property of 2-bromo-N-(4-((1E,4E)-5-(4-bromophenyl)-3-oxopenta-1,4-dienyl)phenyl)acrylamide

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Technology Process of 2-bromo-N-(4-((1E,4E)-5-(4-bromophenyl)-3-oxopenta-1,4-dienyl)phenyl)acrylamide

There total 3 articles about 2-bromo-N-(4-((1E,4E)-5-(4-bromophenyl)-3-oxopenta-1,4-dienyl)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 10443-65-9
2-bromo-2-propenoic acid

: 1285534-38-4
(1E,4E)-1-(4-aminophenyl)-5-(4-bromophenyl)penta-1,4-dien-3-one

: 1228557-51-4
2-bromo-N-(4-((1E,4E)-5-(4-bromophenyl)-3-oxopenta-1,4-dienyl)phenyl)acrylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.2174/157018012799079842

Reference yield:

: 1371578-99-2
(1E,4E)-1-(4-bromophenyl)-5-(4-nitrophenyl)penta-1,4-dien-3-one

: 1228557-51-4
2-bromo-N-(4-((1E,4E)-5-(4-bromophenyl)-3-oxopenta-1,4-dienyl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: iron; ammonium chloride / ethanol; water / 1 h / 85 °C / Inert atmosphere

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With iron; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.2174/157018012799079842

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1228557-51-4
2-bromo-N-(4-((1E,4E)-5-(4-bromophenyl)-3-oxopenta-1,4-dienyl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water / 2 h / 4 - 20 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / ethanol / 0.17 h / 20 °C / Inert atmosphere

2.2: 18 h / 20 °C / Inert atmosphere

3.1: iron; ammonium chloride / ethanol; water / 1 h / 85 °C / Inert atmosphere

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; iron; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide; 1.1: Claisen-Schmidt condensation;
DOI:10.2174/157018012799079842