dolutegravir

Base Information

Chemical Name:dolutegravir
CAS No.:1357289-29-2
Molecular Formula:C₂₀H₁₉F₂N₃O₅
Molecular Weight:419.385
Hs Code.:

Synonyms:dolutegravir

Suppliers and Price of dolutegravir

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of dolutegravir

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of dolutegravir

There total 10 articles about dolutegravir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: C₂₂H₂₃F₂N₃O₅

: 1357289-29-2,1051375-16-6,1309560-49-3
dolutegravir

Guidance literature:: With sodium hydroxide; In ethanol; dichloromethane; at 10 - 30 ℃; for 12.1667h;
DOI:10.1016/j.molstruc.2021.132274

Reference yield:

: C₂₁H₂₁F₂N₃O₅

: 1357289-29-2,1051375-16-6,1309560-49-3
dolutegravir

Guidance literature:: C₂₁H₂₁F₂N₃O₅; With lithium bromide; In tetrahydrofuran; for 3h; Reflux;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: C₂₄H₂₉F₂N₃O₆

: 1357289-29-2,1051375-16-6,1309560-49-3
dolutegravir

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / tetrahydrofuran; water / 4 h / 25 - 30 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 5 - 30 °C

3: sodium hydroxide / ethanol; dichloromethane / 12.17 h / 10 - 30 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.molstruc.2021.132274