dolutegravir

Base Information

• Chemical Name: dolutegravir
• CAS No.: 1357289-29-2
• Molecular Formula: C₂₀H₁₉F₂N₃O₅
• Molecular Weight: 419.385
• Mol file: 1357289-29-2.mol

Synonyms:dolutegravir

Chemical Property of dolutegravir

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dolutegravir

There total 10 articles about dolutegravir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C22H23F2N3O5 → dolutegravir (1357289-29-2,1051375-16-6,1309560-49-3)

Guidance literature:

With sodium hydroxide; In ethanol; dichloromethane; at 10 - 30 ℃; for 12.1667h;

DOI:10.1016/j.molstruc.2021.132274

Reference yield:

C21H21F2N3O5 → dolutegravir (1357289-29-2,1051375-16-6,1309560-49-3)

Guidance literature:

C₂₁H₂₁F₂N₃O₅; With lithium bromide; In tetrahydrofuran; for 3h; Reflux;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

C24H29F2N3O6 → dolutegravir (1357289-29-2,1051375-16-6,1309560-49-3)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium hydroxide / tetrahydrofuran; water / 4 h / 25 - 30 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 5 - 30 °C

3: sodium hydroxide / ethanol; dichloromethane / 12.17 h / 10 - 30 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.molstruc.2021.132274

upstream raw materials:

1-[2,2-bis(methyloxy)ethyl]-5-(methyloxy)-6-[(methyloxy)carbonyl]-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

2,4-Difluoro-benzylamine

methyl 5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dirnethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate