[1S,2R]-trans-2-Aminocyclohexanol hydrochloride

Base Information

• Chemical Name: [1S,2R]-trans-2-Aminocyclohexanol hydrochloride
• CAS No.: 13374-31-7
• Molecular Formula: C6H14ClNO
• Molecular Weight: 151.636
• Hs Code.: 2922199090
• Mol file: 13374-31-7.mol

Synonyms:Cyclohexanol,2-amino-, hydrochloride, (1R,2R)- (8CI,9CI);Cyclohexanol, 2-amino-,hydrochloride, (1R-trans)-;(1R,2R)-2-Aminocyclohexanol hydrochloride;cyclohexanol, 2-amino-, (1R,2R)-, hydrochloride (1:1);

Chemical Property of [1S,2R]-trans-2-Aminocyclohexanol hydrochloride

Chemical Property:

• Vapor Pressure: 0.00628mmHg at 25°C
• Melting Point: 176-177 °C
• Boiling Point: 241.2 °C at 760 mmHg
• Flash Point: 99.7 °C
• PSA: 46.25000
• LogP: 0.94890
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

(1R,2R)-2-AminocyclohexanolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [1S,2R]-trans-2-Aminocyclohexanol hydrochloride

There total 18 articles about [1S,2R]-trans-2-Aminocyclohexanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(1R,2R)-2-(benzyloxy)cyclohexan-1-amine (216394-07-9,216394-06-8) → (1R,2R)-trans-2-aminocyclohexanol hydrochloride (13374-31-7)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; methanol; at 0 ℃;

Reference yield: 89.0%

(1R,2R)-trans-2-(N-tert-butyloxycarbonyl)amino-1-cyclohexanol (155975-19-2,477584-30-8) → (1R,2R)-trans-2-aminocyclohexanol hydrochloride (13374-31-7)

Guidance literature:

With aluminium chloride doped on a neutral alumina; for 0.0333333h; Irradiation;

DOI:10.1016/S0040-4039(98)01094-6

Reference yield: 82.0%

N-(cis-2-hydroxycyclohexyl)benzamide (5450-83-9,23551-93-1,33092-84-1,64757-25-1,116429-77-7) → trans-2-hydroxycyclohexylamine hydrochloride (5456-63-3,6936-47-6,13374-30-6,13374-31-7,33092-83-0,38898-68-9,89584-01-0)

Guidance literature:

With hydrogenchloride; In methanol; water; for 24h; Heating;

upstream raw materials:

N-(cis-2-hydroxycyclohexyl)benzamide

cis-2-benzamidocyclohexyl benzoate

1,2-cis-(1,3-dihydroisobenzofuran-1-ylideneamino)cyclohexanol

(1S,2R)-2-[3H-Isobenzofuran-(1Z)-ylideneamino]-cyclohexanol

Downstream raw materials:

(1R,2R)-2-((6-methoxybenzo[d]thiazol-2-yl)amino)cyclohexan-1-ol

(1R,2R)-2-(7-bromo-6-methoxybenzo[d]thiazol-2ylamino)cyclohexanol

(1R,2R)-2-(2,4-dinitrophenylamino)cyclohexanol

Refernces

• 1、 Birrell, James A.,Jacobsen, Eric N.. "A practical method for the synthesis of highly enantioenriched trans -1,2-amino alcohols". supporting information. p. 2895 - 2897. Retrieved 2013/07/26.
• 2、 -. "CSF-1R INHIBITORS, COMPOSITIONS, AND METHODS OF USE". Page/Page column 82-83. . Retrieved 2009/01/20.