1-O-allyl-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-4,10-dideacetyl-4-O-propionyl-7-O-triethylsilylbaccatin III

Base Information

Chemical Name:1-O-allyl-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-4,10-dideacetyl-4-O-propionyl-7-O-triethylsilylbaccatin III
CAS No.:209688-46-0
Molecular Formula:C₅₁H₆₉F₂NO₁₄Si
Molecular Weight:986.189
Hs Code.:

Synonyms:1-O-allyl-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-4,10-dideacetyl-4-O-propionyl-7-O-triethylsilylbaccatin III

Suppliers and Price of 1-O-allyl-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-4,10-dideacetyl-4-O-propionyl-7-O-triethylsilylbaccatin III

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-O-allyl-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-4,10-dideacetyl-4-O-propionyl-7-O-triethylsilylbaccatin III

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-O-allyl-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-4,10-dideacetyl-4-O-propionyl-7-O-triethylsilylbaccatin III

There total 2 articles about 1-O-allyl-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-4,10-dideacetyl-4-O-propionyl-7-O-triethylsilylbaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 200501-25-3
(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionic acid

: 181420-23-5
10-O-allyl-4,10-dideacetyl-4-O-propionyl-7-O-triethylsilylbaccatin III

: 209688-46-0
1-O-allyl-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-4,10-dideacetyl-4-O-propionyl-7-O-triethylsilylbaccatin III

Guidance literature:: With dmap; 2,2'-dipyridyl carbonate; In toluene; at 80 ℃; for 20h;
DOI:10.1248/cpb.46.770

Reference yield:

: 181420-18-8
4,10-dideacetyl-4-O-propionyl-7-O-triethylsilylbaccatin III

: 209688-46-0
1-O-allyl-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-4,10-dideacetyl-4-O-propionyl-7-O-triethylsilylbaccatin III

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, DMSO, 0 deg C, 3 h

2: 86 percent / dipyridyl carbonate, 4-(dimethylamino)pyridine / toluene / 20 h / 80 °C

With dmap; n-butyllithium; 2,2'-dipyridyl carbonate; In toluene;
DOI:10.1248/cpb.46.770

Reference yield:

: 209688-46-0
1-O-allyl-13-O-[(3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(2-furyl)propionyl]-4,10-dideacetyl-4-O-propionyl-7-O-triethylsilylbaccatin III

: C₅₀H₆₉F₂NO₁₅Si

Guidance literature:: With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone; for 1h; Ambient temperature;
DOI:10.1248/cpb.46.770