[(2S,5R,6S)-5-(2-Acetylamino-6-diphenylcarbamoyloxy-purin-9-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester

Base Information

Chemical Name:[(2S,5R,6S)-5-(2-Acetylamino-6-diphenylcarbamoyloxy-purin-9-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester
CAS No.:1027589-04-3
Molecular Formula:C₅₁H₅₁N₆O₈P
Molecular Weight:906.975
Hs Code.:

[(2S,5R,6S)-5-(2-Acetylamino-6-diphenylcarbamoyloxy-purin-9-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester

Synonyms:[(2S,5R,6S)-5-(2-Acetylamino-6-diphenylcarbamoyloxy-purin-9-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester

Suppliers and Price of [(2S,5R,6S)-5-(2-Acetylamino-6-diphenylcarbamoyloxy-purin-9-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(2S,5R,6S)-5-(2-Acetylamino-6-diphenylcarbamoyloxy-purin-9-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(2S,5R,6S)-5-(2-Acetylamino-6-diphenylcarbamoyloxy-purin-9-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester

There total 6 articles about [(2S,5R,6S)-5-(2-Acetylamino-6-diphenylcarbamoyloxy-purin-9-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112233-74-6
N²-acetyl-O⁶-(diphenylcarbamoyl)guanine

: 174579-34-1
((2S,5S,6R)-5-Hydroxy-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl)-phosphonic acid diisopropyl ester

: 1027589-04-3
[(2S,5R,6S)-5-(2-Acetylamino-6-diphenylcarbamoyloxy-purin-9-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/jm950788+

Reference yield:

: 116-17-6
triisopropyl phosphite

: 1027589-04-3
[(2S,5R,6S)-5-(2-Acetylamino-6-diphenylcarbamoyloxy-purin-9-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / BF₃*Et₂O / toluene / 4 h / 100 °C

2: NH₃ / methanol / 6 h / Ambient temperature

3: 46 percent / pyridine / toluene / 24 h / Ambient temperature

4: diethyl azodicarboxylate, Ph₃P / tetrahydrofuran / 0 - 20 °C

With pyridine; boron trifluoride diethyl etherate; ammonia; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm950788+

Reference yield:

: 76-83-5
trityl chloride

: 1027589-04-3
[(2S,5R,6S)-5-(2-Acetylamino-6-diphenylcarbamoyloxy-purin-9-yl)-6-trityloxymethyl-5,6-dihydro-2H-pyran-2-yl]-phosphonic acid diisopropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 46 percent / pyridine / toluene / 24 h / Ambient temperature

2: diethyl azodicarboxylate, Ph₃P / tetrahydrofuran / 0 - 20 °C

With pyridine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene;
DOI:10.1021/jm950788+