(4R,6S)-2-[benzyloxycarbonylamino]-4-[(3,3)-dimethoxypropyl]-6-methyl-3,4,5,6-tetrahydropyrimidine

Base Information

Chemical Name:(4R,6S)-2-[benzyloxycarbonylamino]-4-[(3,3)-dimethoxypropyl]-6-methyl-3,4,5,6-tetrahydropyrimidine
CAS No.:379668-89-0
Molecular Formula:C₁₈H₂₇N₃O₄
Molecular Weight:349.43
Hs Code.:

Synonyms:(4R,6S)-2-[benzyloxycarbonylamino]-4-[(3,3)-dimethoxypropyl]-6-methyl-3,4,5,6-tetrahydropyrimidine

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Chemical Property of (4R,6S)-2-[benzyloxycarbonylamino]-4-[(3,3)-dimethoxypropyl]-6-methyl-3,4,5,6-tetrahydropyrimidine

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Technology Process of (4R,6S)-2-[benzyloxycarbonylamino]-4-[(3,3)-dimethoxypropyl]-6-methyl-3,4,5,6-tetrahydropyrimidine

There total 6 articles about (4R,6S)-2-[benzyloxycarbonylamino]-4-[(3,3)-dimethoxypropyl]-6-methyl-3,4,5,6-tetrahydropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: benzyl N-[methoxy(methylthio)methylene]carbamate

: 379668-87-8
(2S,4R)-7,7-dimethoxyheptane-2,4-diamine

: 379668-89-0
(4R,6S)-2-[benzyloxycarbonylamino]-4-[(3,3)-dimethoxypropyl]-6-methyl-3,4,5,6-tetrahydropyrimidine

Guidance literature:: In dichloromethane; for 24h;
DOI:10.1021/ja017067m

Reference yield: 82.0%

: benzyl N-[methoxy-(methylthio)methylene]carbamate

: 379668-87-8
(2S,4R)-7,7-dimethoxyheptane-2,4-diamine

: 379668-89-0
(4R,6S)-2-[benzyloxycarbonylamino]-4-[(3,3)-dimethoxypropyl]-6-methyl-3,4,5,6-tetrahydropyrimidine

Guidance literature:: In dichloromethane; for 24h;
DOI:10.1021/ja0574320

Reference yield:

: 379669-03-1
(R)-6-hydroxy-1,1-dimethoxyheptan-4-one

: 379668-89-0
(4R,6S)-2-[benzyloxycarbonylamino]-4-[(3,3)-dimethoxypropyl]-6-methyl-3,4,5,6-tetrahydropyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₂BOMe / tetrahydrofuran; methanol / 0.5 h / -78 °C

1.2: NaBH₄ / tetrahydrofuran; methanol / 1 h / -78 °C

2.1: 82 percent / diethyl azodicarboxylate; hydrazoic acid; triphenylphosphine / tetrahydrofuran; toluene / 0.33 h / 0 °C

3.1: 98 percent / H₂ / Pd/C / methanol / 24 h / 3102.89 Torr

4.1: 82 percent / CH₂Cl₂ / 24 h

With hydrogen azide; diethyl methoxy borane; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene; 2.1: Mitsunobu reaction;
DOI:10.1021/ja0574320