2-(4-(5-amino-6-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile

Base Information

Chemical Name:2-(4-(5-amino-6-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile
CAS No.:1402390-51-5
Molecular Formula:C₂₃H₁₉ClN₆O
Molecular Weight:430.896
Hs Code.:

Synonyms:2-(4-(5-amino-6-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile

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Chemical Property of 2-(4-(5-amino-6-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile

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Technology Process of 2-(4-(5-amino-6-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile

There total 5 articles about 2-(4-(5-amino-6-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 839718-02-4
4-(chloromethyl)-N-hydroxybenzimidoyl chloride

: 1402390-36-6
C₂₅H₂₉N₅O₄

: 1402390-51-5
2-(4-(5-amino-6-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile

Guidance literature:: 4-(chloromethyl)-N-hydroxybenzimidoyl chloride; C₂₅H₂₉N₅O₄; With triethylamine; at 20 ℃; for 84h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 153034-86-7
2-chloro-4-iodopyridine

: 1402390-51-5
2-(4-(5-amino-6-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / toluene; tetrahydrofuran / 0 - 20 °C

2.1: bis(pinacol)diborane; potassium acetate / (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane / 17 h / 100 °C / Inert atmosphere

2.2: 4.5 h / 60 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 0 °C

4.1: triethylamine / 84 h / 20 °C

4.2: 1 h / 20 °C

With tetrabutyl ammonium fluoride; potassium acetate; sodium hexamethyldisilazane; triethylamine; bis(pinacol)diborane; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; toluene;

Reference yield:

: 1217486-73-1
2-(4-iodo-2-pyridyl)-2-methyl-propanenitrile

: 1402390-51-5
2-(4-(5-amino-6-(3-(4-(chloromethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)pyridin-2-yl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis(pinacol)diborane; potassium acetate / (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane / 17 h / 100 °C / Inert atmosphere

1.2: 4.5 h / 60 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 0 °C

3.1: triethylamine / 84 h / 20 °C

3.2: 1 h / 20 °C

With tetrabutyl ammonium fluoride; potassium acetate; triethylamine; bis(pinacol)diborane; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane;