2-(3-amino-5-(1-methyl-1H-pyrazol-4-yl)phenoxy)-N-methylacetamide

Base Information

Chemical Name:2-(3-amino-5-(1-methyl-1H-pyrazol-4-yl)phenoxy)-N-methylacetamide
CAS No.:1036756-52-1
Molecular Formula:C₁₃H₁₆N₄O₂
Molecular Weight:260.296
Hs Code.:

Synonyms:2-(3-amino-5-(1-methyl-1H-pyrazol-4-yl)phenoxy)-N-methylacetamide

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Chemical Property of 2-(3-amino-5-(1-methyl-1H-pyrazol-4-yl)phenoxy)-N-methylacetamide

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Technology Process of 2-(3-amino-5-(1-methyl-1H-pyrazol-4-yl)phenoxy)-N-methylacetamide

There total 3 articles about 2-(3-amino-5-(1-methyl-1H-pyrazol-4-yl)phenoxy)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1036756-65-6
3-(1-methyl-1H-pyrazol-4-yl)-5-nitrophenol

: 1036756-52-1
2-(3-amino-5-(1-methyl-1H-pyrazol-4-yl)phenoxy)-N-methylacetamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 22h; Inert atmosphere of argon;

Reference yield:

: 16618-67-0
3-bromo-5-nitroanisole

: 1036756-52-1
2-(3-amino-5-(1-methyl-1H-pyrazol-4-yl)phenoxy)-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron tribromide / dichloromethane / 20 °C / Cooling with ice bath

1.2: -78 - 20 °C

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1.5 h / 80 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 22 h / 20 °C / Inert atmosphere of argon

With hydrogen; boron tribromide; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; 2.1: Suzuki Coupling;

Reference yield:

: 116632-23-6
3-bromo-5-nitro-phenol

: 1036756-52-1
2-(3-amino-5-(1-methyl-1H-pyrazol-4-yl)phenoxy)-N-methylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1.5 h / 80 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 22 h / 20 °C / Inert atmosphere of argon

With hydrogen; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; 1: Suzuki Coupling;