(3aS,8aR)-1,8-Dibenzyl-5-methoxy-3a-methyl-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole

Base Information

Chemical Name:(3aS,8aR)-1,8-Dibenzyl-5-methoxy-3a-methyl-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole
CAS No.:207729-66-6
Molecular Formula:C₂₆H₂₈N₂O
Molecular Weight:384.521
Hs Code.:

Synonyms:(3aS,8aR)-1,8-Dibenzyl-5-methoxy-3a-methyl-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole

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Chemical Property of (3aS,8aR)-1,8-Dibenzyl-5-methoxy-3a-methyl-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole

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Technology Process of (3aS,8aR)-1,8-Dibenzyl-5-methoxy-3a-methyl-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole

There total 1 articles about (3aS,8aR)-1,8-Dibenzyl-5-methoxy-3a-methyl-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 100-46-9
benzylamine

: [2-((2S,3S)-1-Benzyl-2-hydroxy-5-methoxy-3-methyl-2,3-dihydro-1H-indol-3-yl)-ethyl]-trimethyl-ammonium; iodide

: 207729-66-6
(3aS,8aR)-1,8-Dibenzyl-5-methoxy-3a-methyl-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole

Guidance literature:: In acetonitrile; for 6h; Heating;
DOI:10.1021/jm9800494

Reference yield: 90.0%

: 207729-66-6
(3aS,8aR)-1,8-Dibenzyl-5-methoxy-3a-methyl-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole

: 207729-67-7
(3aS,8aR)-1,8-Dibenzyl-3a-methyl-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indol-5-ol

Guidance literature:: With boron tribromide; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1021/jm9800494

Reference yield:

: 207729-66-6
(3aS,8aR)-1,8-Dibenzyl-5-methoxy-3a-methyl-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole

: (-)-N₈-norphenylcarbamoyleseroline

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / BBr₃ / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) Na / 1.) ether, RT, 1 min, 2.) ether, 5 min

3: 70 percent / H₂ / Pd(OH)2C / 60 h / 760 Torr / Ambient temperature

With hydrogen; sodium; boron tribromide; palladium hydroxide - carbon; In dichloromethane;
DOI:10.1021/jm9800494