[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methyl-1-[2-(3-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

Base Information

Chemical Name:[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methyl-1-[2-(3-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride
CAS No.:1404529-27-6
Molecular Formula:C₃₁H₃₆N₆O₃*ClH
Molecular Weight:577.126
Hs Code.:

Synonyms:[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methyl-1-[2-(3-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

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Chemical Property of [4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methyl-1-[2-(3-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

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Technology Process of [4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methyl-1-[2-(3-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

There total 23 articles about [4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methyl-1-[2-(3-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1404538-89-1
C₃₆H₄₄N₆O₅

: 1404529-27-6
[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methyl-1-[2-(3-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; ethyl acetate; at 20 ℃; for 20h;
DOI:10.1021/jm500588w

Reference yield:

: 1404532-64-4
{3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-methyl-indol-1-yl}acetic acid methyl ester

: 1404529-27-6
[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methyl-1-[2-(3-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / methanol / 20 °C

2: triethylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 20 h / 20 °C

3: hydrogenchloride / 1,4-dioxane; methanol; ethyl acetate / 20 h / 20 °C

With hydrogenchloride; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm500588w

Reference yield:

: 1-acetyl-5-methyl-1H-indole-3-carboxylic acid

: 1404529-27-6
[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-methyl-1-[2-(3-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0 - 20 °C

2: potassium carbonate / methanol / 4 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4: sodium hydroxide; water / methanol / 20 °C

5: triethylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 20 h / 20 °C

6: hydrogenchloride / 1,4-dioxane; methanol; ethyl acetate / 20 h / 20 °C

With hydrogenchloride; dmap; water; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm500588w