1H-Benzimidazole,2-(1-methyl-1H-pyrrol-2-yl)-(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole,2-(1-methyl-1H-pyrrol-2-yl)-(9CI)
• CAS No.: 13253-57-1
• Molecular Formula: C12H11 N3
• Molecular Weight: 197.239
• Hs Code.: 2933990090
• Mol file: 13253-57-1.mol

Synonyms:Benzimidazole,2-(1-methylpyrrol-2-yl)- (7CI,8CI); 2-(1-Methylpyrrol-2-yl)-1H-benzimidazole

Chemical Property of 1H-Benzimidazole,2-(1-methyl-1H-pyrrol-2-yl)-(9CI)

Chemical Property:

• PSA: 33.61000
• LogP: 2.56840

Purity/Quality:

99% ^*data from raw suppliers

2-(1-METHYL-1H-PYRROL-2-YL)-1H-BENZIMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole,2-(1-methyl-1H-pyrrol-2-yl)-(9CI)

There total 4 articles about 1H-Benzimidazole,2-(1-methyl-1H-pyrrol-2-yl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-methylpyrrole aldehyde (1192-58-1) + 1,2-diamino-benzene (95-54-5) → 2-(1-methyl-1H-pyrrol-2-yl)-1H-benzo[d]imidazole (13253-57-1)

Guidance literature:

With bismuth (III) nitrate pentahydrate; In water; at 80 ℃; for 0.166667h; Microwave irradiation; Green chemistry;

DOI:10.2174/0929867325666171201101807

Reference yield: 84.0%

N-Methylpyrrole (96-54-8) + 2-bromo-1H-1,3-benzodiazole (54624-57-6) → 2-(1-methyl-1H-pyrrol-2-yl)-1H-benzo[d]imidazole (13253-57-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; for 48h; regioselective reaction; Irradiation; Inert atmosphere;

DOI:10.1021/acscatal.6b01452

Reference yield: 65.0%

N-Methylpyrrole (96-54-8) + 2-chloro-1H-benzoimidazole (4857-06-1) → 2-(1-methyl-1H-pyrrol-2-yl)-1H-benzo[d]imidazole (13253-57-1)

Guidance literature:

With rhodamine 6G; N-ethyl-N,N-diisopropylamine; In water; dimethyl sulfoxide; at 25 ℃; for 48h; Sealed tube; Irradiation;

DOI:10.1021/acs.joc.7b00088

upstream raw materials:

N-methylpyrrole aldehyde

1,2-diamino-benzene

1-Methyl-2-pyrrolecarboxylic acid

N-Methylpyrrole

Downstream raw materials:

C₃₂H₃₉N₅O₅S₂

(2S)-N-{4-(3-[2-(1-methyl-2-pyrrolyl)benzimidazol-1-yl]pentyl)oxy-5-methoxy-2-aminobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

(2S)-N-{4-(3-[2-(1-methyl-2-pyrrolyl)benzimidazol-1-yl]pentyl)oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal

2-(1-methylpyrrol-2-yl)-1-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}-1H-benzimidazole