(2S,4S,5S)-5-[(S)-2-[(S)-2-(2,2-Dimethyl-propionylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-1-[(S)-1-carbamoyl-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-butyl}-amide

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Chemical Name:(2S,4S,5S)-5-[(S)-2-[(S)-2-(2,2-Dimethyl-propionylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-1-[(S)-1-carbamoyl-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-butyl}-amide
CAS No.:102522-56-5
Molecular Formula:C₄₄H₆₈N₁₀O₇
Molecular Weight:849.087
Hs Code.:

(2S,4S,5S)-5-[(S)-2-[(S)-2-(2,2-Dimethyl-propionylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-1-[(S)-1-carbamoyl-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-butyl}-amide

Synonyms:(2S,4S,5S)-5-[(S)-2-[(S)-2-(2,2-Dimethyl-propionylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-1-[(S)-1-carbamoyl-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-butyl}-amide

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Chemical Property of (2S,4S,5S)-5-[(S)-2-[(S)-2-(2,2-Dimethyl-propionylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-1-[(S)-1-carbamoyl-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-butyl}-amide

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Technology Process of (2S,4S,5S)-5-[(S)-2-[(S)-2-(2,2-Dimethyl-propionylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-1-[(S)-1-carbamoyl-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-butyl}-amide

There total 7 articles about (2S,4S,5S)-5-[(S)-2-[(S)-2-(2,2-Dimethyl-propionylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-1-[(S)-1-carbamoyl-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-butyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 102522-55-4
Piv-Phe-His-OH

: 102522-16-7
(2S,4S,5S)-5-Amino-4-hydroxy-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-1-[(S)-1-carbamoyl-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-butyl}-amide

: 102522-56-5
(2S,4S,5S)-5-[(S)-2-[(S)-2-(2,2-Dimethyl-propionylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-1-[(S)-1-carbamoyl-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-butyl}-amide

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1.) ice cooling, 24 h, 2.) room temperature, 24 h;
DOI:10.1021/jm00117a027

Reference yield:

: (4S,5S)-5-(2-Carboxy-3-methyl-butyl)-4-isobutyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

: 102522-56-5
(2S,4S,5S)-5-[(S)-2-[(S)-2-(2,2-Dimethyl-propionylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-1-[(S)-1-carbamoyl-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-butyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / 1-hydroxybenzotriazole hydrate, 1,3-dicyclohexylcarbodiimide / dimethylformamide / 1.) ice cooling, 24 deg C, 2.) room temperature, 72 h

2: 78 percent / hydrogen / 10percent Pd-C / methanol; H₂O / 0.5 h

3: 61 percent / 1-hydroxybenzotriazole hydrate, 1,3-dicyclohexylcarbodiimide / dimethylformamide / 1.) ice cooling, 24 h, 2.) room temperature, 24 h

With hydrogen; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00117a027

Reference yield:

: 102522-24-7
(4S,5S)-5-((S)-2-{(1S,2S)-1-[(S)-1-Carbamoyl-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-3-methyl-butyl)-4-isobutyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

: 102522-56-5
(2S,4S,5S)-5-[(S)-2-[(S)-2-(2,2-Dimethyl-propionylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-1-[(S)-1-carbamoyl-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-butyl}-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / hydrogen / 10percent Pd-C / methanol; H₂O / 0.5 h

2: 61 percent / 1-hydroxybenzotriazole hydrate, 1,3-dicyclohexylcarbodiimide / dimethylformamide / 1.) ice cooling, 24 h, 2.) room temperature, 24 h

With hydrogen; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00117a027