(R)-2'-{1-chloro-3-ethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide

Base Information

Chemical Name:(R)-2'-{1-chloro-3-ethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide
CAS No.:1036401-40-7
Molecular Formula:C₂₆H₂₈ClF₃N₄O
Molecular Weight:504.983
Hs Code.:

Synonyms:(R)-2'-{1-chloro-3-ethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide

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Chemical Property of (R)-2'-{1-chloro-3-ethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide

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Technology Process of (R)-2'-{1-chloro-3-ethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide

There total 13 articles about (R)-2'-{1-chloro-3-ethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1036400-57-3
1-chloro-3-ethyl-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine

: 98-59-9
p-toluenesulfonyl chloride

: 1036401-40-7
(R)-2'-{1-chloro-3-ethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butanone; at 80 ℃; for 48h;

Reference yield:

: C₂₂H₂₇ClF₃N₃O₂

: 1036401-40-7
(R)-2'-{1-chloro-3-ethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / dichloromethane; water; 1,4-dioxane / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine; 3-methyl-butan-2-one / 80 °C

With 3-methyl-butan-2-one; hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmcl.2013.04.071

Reference yield:

: 1036398-94-3
1-chloro-3-ethyl-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester

: 1036401-40-7
(R)-2'-{1-chloro-3-ethyl-(S)-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl}-N-methyl-2'-phenylacetamide

: 1428543-97-8
C₂₆H₂₈ClF₃N₄O

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / 80 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2013.01.088