methyl (2R,5S,6S)-2-(2-bromobenzyl)-5-methyl-6-phenyl-1-(trifluoroacetyl)-1,2,5,6-tetrahydropyridine-2-carboxylate

Base Information

Chemical Name:methyl (2R,5S,6S)-2-(2-bromobenzyl)-5-methyl-6-phenyl-1-(trifluoroacetyl)-1,2,5,6-tetrahydropyridine-2-carboxylate
CAS No.:952408-71-8
Molecular Formula:C₂₃H₂₁BrF₃NO₃
Molecular Weight:496.324
Hs Code.:

Synonyms:methyl (2R,5S,6S)-2-(2-bromobenzyl)-5-methyl-6-phenyl-1-(trifluoroacetyl)-1,2,5,6-tetrahydropyridine-2-carboxylate

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Chemical Property of methyl (2R,5S,6S)-2-(2-bromobenzyl)-5-methyl-6-phenyl-1-(trifluoroacetyl)-1,2,5,6-tetrahydropyridine-2-carboxylate

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Technology Process of methyl (2R,5S,6S)-2-(2-bromobenzyl)-5-methyl-6-phenyl-1-(trifluoroacetyl)-1,2,5,6-tetrahydropyridine-2-carboxylate

There total 1 articles about methyl (2R,5S,6S)-2-(2-bromobenzyl)-5-methyl-6-phenyl-1-(trifluoroacetyl)-1,2,5,6-tetrahydropyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: C₁₆H₁₅NO₃F₃H

: 3433-80-5
1-Bromo-2-bromomethyl-benzene

: 952408-71-8
methyl (2R,5S,6S)-2-(2-bromobenzyl)-5-methyl-6-phenyl-1-(trifluoroacetyl)-1,2,5,6-tetrahydropyridine-2-carboxylate

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 0 ℃; for 5h;
DOI:10.1021/ol701722z

Reference yield: 81.0%

: 952408-71-8
methyl (2R,5S,6S)-2-(2-bromobenzyl)-5-methyl-6-phenyl-1-(trifluoroacetyl)-1,2,5,6-tetrahydropyridine-2-carboxylate

: 952408-73-0
methyl (2S,3S,4aS,9aR)-3-methyl-2-phenyl-1-(trifluoroacetyl)-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine-9a-carboxylate

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; at 80 ℃; for 4h;
DOI:10.1021/ol701722z

Reference yield:

: 952408-71-8
methyl (2R,5S,6S)-2-(2-bromobenzyl)-5-methyl-6-phenyl-1-(trifluoroacetyl)-1,2,5,6-tetrahydropyridine-2-carboxylate

: C₂₈H₂₆N₂O₃

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / 2,2'-azobis(isobutyronitrile); tri(n-butyl)tin hydride / benzene / 4 h / 80 °C

2.1: potassium hydroxide / H₂O; methanol / 2 h / 20 °C

2.2: 68 percent / triethylamine / tetrahydrofuran / 6 h / 45 °C

With potassium hydroxide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In methanol; water; benzene;
DOI:10.1021/ol701722z