N-(1-benzyl-4,4-diethoxy-piperidin-3-yl)-6-(2-ethyl-5-fluoro-4-hydroxy-phenyl)-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboxamidine

Base Information

Chemical Name:N-(1-benzyl-4,4-diethoxy-piperidin-3-yl)-6-(2-ethyl-5-fluoro-4-hydroxy-phenyl)-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboxamidine
CAS No.:1421502-61-5
Molecular Formula:C₃₇H₄₆FN₅O₄
Molecular Weight:643.802
Hs Code.:

Synonyms:N-(1-benzyl-4,4-diethoxy-piperidin-3-yl)-6-(2-ethyl-5-fluoro-4-hydroxy-phenyl)-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboxamidine

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Chemical Property of N-(1-benzyl-4,4-diethoxy-piperidin-3-yl)-6-(2-ethyl-5-fluoro-4-hydroxy-phenyl)-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboxamidine

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Technology Process of N-(1-benzyl-4,4-diethoxy-piperidin-3-yl)-6-(2-ethyl-5-fluoro-4-hydroxy-phenyl)-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboxamidine

There total 14 articles about N-(1-benzyl-4,4-diethoxy-piperidin-3-yl)-6-(2-ethyl-5-fluoro-4-hydroxy-phenyl)-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1421503-43-6
N-(1-benzyl-4,4-diethoxy-piperidin-3-yl)-6-[2-ethyl-5-fluoro-4-(2-trimethylsilanyl-ethoxymethoxy)phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboxamidine

: 1421502-61-5
N-(1-benzyl-4,4-diethoxy-piperidin-3-yl)-6-(2-ethyl-5-fluoro-4-hydroxy-phenyl)-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboxamidine

Guidance literature:: With hydrogenchloride; In ethanol; water; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b01634

Reference yield:

: 1421503-37-8
6-bromo-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carbonitrile

: 1421502-61-5
N-(1-benzyl-4,4-diethoxy-piperidin-3-yl)-6-(2-ethyl-5-fluoro-4-hydroxy-phenyl)-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboxamidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

2.1: methanol / 18 h / 20 °C

3.1: acetic acid / ethanol / 18 h / 50 °C

4.1: hydrogenchloride; water / ethanol / 18 h / 20 °C

4.2: 0 °C

With hydrogenchloride; methanol; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; acetic acid; In 1,4-dioxane; ethanol; water;

Reference yield:

: 1421503-36-7
6-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-3-carbaldehyde

: 1421502-61-5
N-(1-benzyl-4,4-diethoxy-piperidin-3-yl)-6-(2-ethyl-5-fluoro-4-hydroxy-phenyl)-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboxamidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; hydroxylamine hydrochloride / acetonitrile / 3 h / 60 °C

1.2: 2 h / 0 - 20 °C

2.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

3.1: methanol / 18 h / 20 °C

4.1: acetic acid / ethanol / 18 h / 50 °C

5.1: hydrogenchloride; water / ethanol / 18 h / 20 °C

5.2: 0 °C

With hydrogenchloride; methanol; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; water; acetic acid; triethylamine; In 1,4-dioxane; ethanol; water; acetonitrile;