7-methylsulfonyl-N-triphenylmethyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:7-methylsulfonyl-N-triphenylmethyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:220247-64-3
Molecular Formula:C₂₉H₂₇NO₂S
Molecular Weight:453.605
Hs Code.:

Synonyms:7-methylsulfonyl-N-triphenylmethyl-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 7-methylsulfonyl-N-triphenylmethyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of 7-methylsulfonyl-N-triphenylmethyl-1,2,3,4-tetrahydroisoquinoline

There total 5 articles about 7-methylsulfonyl-N-triphenylmethyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 76-83-5
trityl chloride

: 220247-55-2
7-methanesulfonyl-1,2,3,4-tetrahydro-isoquinoline

: 220247-64-3
7-methylsulfonyl-N-triphenylmethyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 18h; Ambient temperature;
DOI:10.1021/jm980429p

Reference yield:

: 72299-68-4
1,2,3,4-Tetrahydro-isoquinolin-7-ylamine

: 220247-64-3
7-methylsulfonyl-N-triphenylmethyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) aq. 48 percent HBr, aq. NaNO₂, 2.) aq. HBr, CuBr / 2.) 75-80 deg C, 1.5 h

2: 94.9 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / Ambient temperature

3: 1.) n-BuLi, 3.) conc. HCl

4: 84.9 percent / trifluoroperacetic acid, TFA / 24 h / Ambient temperature

5: 66 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / Ambient temperature

With hydrogenchloride; dmap; n-butyllithium; trifluoroacetyl peroxide; hydrogen bromide; triethylamine; trifluoroacetic acid; copper(I) bromide; sodium nitrite; In dichloromethane;
DOI:10.1021/jm980429p

Reference yield:

: 17680-55-6
7-bromo-1,2,3,4-tetrahydroisoquinoline

: 220247-64-3
7-methylsulfonyl-N-triphenylmethyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 94.9 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / Ambient temperature

2: 1.) n-BuLi, 3.) conc. HCl

3: 84.9 percent / trifluoroperacetic acid, TFA / 24 h / Ambient temperature

4: 66 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / Ambient temperature

With hydrogenchloride; dmap; n-butyllithium; trifluoroacetyl peroxide; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm980429p