(S)-N-(tert-butoxycarbonyl)-β-(6-chloro-7-carbapurin-9-yl)alanine benzyl ester

Base Information

Chemical Name:(S)-N-(tert-butoxycarbonyl)-β-(6-chloro-7-carbapurin-9-yl)alanine benzyl ester
CAS No.:627869-64-1
Molecular Formula:C₂₁H₂₃ClN₄O₄
Molecular Weight:430.891
Hs Code.:

Synonyms:(S)-N-(tert-butoxycarbonyl)-β-(6-chloro-7-carbapurin-9-yl)alanine benzyl ester

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Chemical Property of (S)-N-(tert-butoxycarbonyl)-β-(6-chloro-7-carbapurin-9-yl)alanine benzyl ester

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Technology Process of (S)-N-(tert-butoxycarbonyl)-β-(6-chloro-7-carbapurin-9-yl)alanine benzyl ester

There total 3 articles about (S)-N-(tert-butoxycarbonyl)-β-(6-chloro-7-carbapurin-9-yl)alanine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 100-51-6,185532-71-2
benzyl alcohol

: 627869-63-0
(S)-N-(tert-butoxycarbonyl)-β-(6-chloro-7-carbapurin-9-yl)alanine

: 627869-64-1
(S)-N-(tert-butoxycarbonyl)-β-(6-chloro-7-carbapurin-9-yl)alanine benzyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1002/ejoc.200300242

Reference yield:

: 98541-64-1
(S)-3-(tert-butoxycarbonylamino)-oxetan-2-one

: 627869-64-1
(S)-N-(tert-butoxycarbonyl)-β-(6-chloro-7-carbapurin-9-yl)alanine benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / DBU / dimethylsulfoxide / 1 h / 20 °C

2: 91 percent / DMAP; EDCI*HCl / dimethylformamide / 18 h / 20 °C

With dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200300242

Reference yield:

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 627869-64-1
(S)-N-(tert-butoxycarbonyl)-β-(6-chloro-7-carbapurin-9-yl)alanine benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / DBU / dimethylsulfoxide / 1 h / 20 °C

2: 91 percent / DMAP; EDCI*HCl / dimethylformamide / 18 h / 20 °C

With dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200300242