(R)-4-(2',5'-dimethoxyphenyl)-3-hydroxy-3-methylbutanal

Base Information

Chemical Name:(R)-4-(2',5'-dimethoxyphenyl)-3-hydroxy-3-methylbutanal
CAS No.:281200-24-6
Molecular Formula:C₁₃H₁₈O₄
Molecular Weight:238.284
Hs Code.:

Synonyms:(R)-4-(2',5'-dimethoxyphenyl)-3-hydroxy-3-methylbutanal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-(2',5'-dimethoxyphenyl)-3-hydroxy-3-methylbutanal

Chemical Property:

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Technology Process of (R)-4-(2',5'-dimethoxyphenyl)-3-hydroxy-3-methylbutanal

There total 11 articles about (R)-4-(2',5'-dimethoxyphenyl)-3-hydroxy-3-methylbutanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: (R)-4-(2',5'-dimethoxyphenyl)-3-methylbutane-1,3-diol

: 281200-24-6
(R)-4-(2',5'-dimethoxyphenyl)-3-hydroxy-3-methylbutanal

Guidance literature:: With Dess-Martin periodane; In dichloromethane; water; at 20 ℃;
DOI:10.1071/CH99091

Reference yield:

: 64018-43-5
2-[(4S)-2,2,4-trimethyl-1,3-dioxolan-4-yl]ethanol

: 281200-24-6
(R)-4-(2',5'-dimethoxyphenyl)-3-hydroxy-3-methylbutanal

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH / tetrahydrofuran

1.2: tetrabutylammonium iodide / tetrahydrofuran

2.1: aq. H₂SO₄ / tetrahydrofuran / 40 °C

3.1: Et₃N / CH₂Cl₂ / -10 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 20 °C

5.1: Mg; I₂ / tetrahydrofuran / 4 h / Heating

5.2: dilithium tetrachlorocuprate / tetrahydrofuran / -78 - -20 °C

6.1: H₂ / 10 percent Pd/C / methanol

7.1: 88 percent / 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one / CH₂Cl₂; H₂O / 20 °C

With sulfuric acid; hydrogen; iodine; sodium hydride; Dess-Martin periodane; magnesium; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; 1.1: deprotonation / 1.2: benzylation / 2.1: Hydrolysis / 3.1: Esterification / 4.1: cyclocondensation / 5.1: Metallation / 5.2: Ring cleavage / 6.1: Hydrogenolysis / 7.1: Oxidation;
DOI:10.1071/CH99091

Reference yield:

: 6236-09-5,2306-22-1
(S)-citramalic acid

: 281200-24-6
(R)-4-(2',5'-dimethoxyphenyl)-3-hydroxy-3-methylbutanal

Guidance literature:: Multi-step reaction with 10 steps

1.1: CH₂Cl₂; ethanol

2.1: LiAlH₄ / tetrahydrofuran / Heating

3.1: p-toluenesulfonic acid / 20 °C

4.1: NaH / tetrahydrofuran

4.2: tetrabutylammonium iodide / tetrahydrofuran

5.1: aq. H₂SO₄ / tetrahydrofuran / 40 °C

6.1: Et₃N / CH₂Cl₂ / -10 °C

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / CH₂Cl₂ / 20 °C

8.1: Mg; I₂ / tetrahydrofuran / 4 h / Heating

8.2: dilithium tetrachlorocuprate / tetrahydrofuran / -78 - -20 °C

9.1: H₂ / 10 percent Pd/C / methanol

10.1: 88 percent / 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one / CH₂Cl₂; H₂O / 20 °C

With lithium aluminium tetrahydride; sulfuric acid; hydrogen; iodine; sodium hydride; Dess-Martin periodane; toluene-4-sulfonic acid; magnesium; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1.1: Esterification / 2.1: Reduction / 3.1: cyclocondensation / 4.1: deprotonation / 4.2: benzylation / 5.1: Hydrolysis / 6.1: Esterification / 7.1: cyclocondensation / 8.1: Metallation / 8.2: Ring cleavage / 9.1: Hydrogenolysis / 10.1: Oxidation;
DOI:10.1071/CH99091