S-trityl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanethioate

Base Information

• Chemical Name: S-trityl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanethioate
• CAS No.: 1333014-20-2
• Molecular Formula: C₅₉H₄₇N₃O₃S
• Molecular Weight: 878.106
• Mol file: 1333014-20-2.mol

Synonyms:S-trityl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanethioate

Chemical Property of S-trityl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanethioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-trityl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanethioate

There total 1 articles about S-trityl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

triphenylmethanethiol (3695-77-0) + Fmoc-His(Trt)-OH (109425-51-6) → S-trityl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanethioate (1333014-20-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 2h;

DOI:10.1021/ol202163e

Reference yield:

S-trityl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanethioate (1333014-20-2) → Fmoc-His(NTrt)-SH

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b01013

upstream raw materials:

triphenylmethanethiol

Fmoc-His(Trt)-OH

Refernces

• 1、 Karmakar, Partha,Talan, Rommel S.,Sucheck, Steven J.. "Mixed-Phase synthesis of glycopeptides using a n-peptidyl-2, 4-dinitrobenzenesulfonamide-Thioacid ligation strategy". supporting information; experimental part. p. 5298 - 5301. Retrieved 2011/12/15.