4-fluoro-3-((2-(pyridin-2-ylamino)thiazol-5-ylmethyl)amino)benzoic acid

Base Information

Chemical Name:4-fluoro-3-((2-(pyridin-2-ylamino)thiazol-5-ylmethyl)amino)benzoic acid
CAS No.:639859-08-8
Molecular Formula:C₁₆H₁₃FN₄O₂S
Molecular Weight:344.369
Hs Code.:

Synonyms:4-fluoro-3-((2-(pyridin-2-ylamino)thiazol-5-ylmethyl)amino)benzoic acid

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Chemical Property of 4-fluoro-3-((2-(pyridin-2-ylamino)thiazol-5-ylmethyl)amino)benzoic acid

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Technology Process of 4-fluoro-3-((2-(pyridin-2-ylamino)thiazol-5-ylmethyl)amino)benzoic acid

There total 2 articles about 4-fluoro-3-((2-(pyridin-2-ylamino)thiazol-5-ylmethyl)amino)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 639858-43-8
2-(pyridin-2-ylamino)thiazole-5-carbaldehyde

: 2365-85-7
3-amino-4-fluorobenzoic acid

: 639859-08-8
4-fluoro-3-((2-(pyridin-2-ylamino)thiazol-5-ylmethyl)amino)benzoic acid

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 25 ℃; for 4h;
DOI:10.1021/jm060347y

Reference yield:

: 14294-11-2
2-pyridylthiourea

: 639859-08-8
4-fluoro-3-((2-(pyridin-2-ylamino)thiazol-5-ylmethyl)amino)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / sodium acetate / acetone / 2 h / Heating

2: 91 percent / TFA; triethylsilane / CH₂Cl₂ / 4 h / 25 °C

With triethylsilane; sodium acetate; trifluoroacetic acid; In dichloromethane; acetone;
DOI:10.1021/jm060347y

Reference yield: 83.0%

: 639859-08-8
4-fluoro-3-((2-(pyridin-2-ylamino)thiazol-5-ylmethyl)amino)benzoic acid

: 2516-47-4
cyclopropanemethylamine

: N-cyclopropylmethyl-4-fluoro-3-{[2-(pyridin-2-ylamino)-thiazol-5-ylmethyl]-amino}-benzamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 2h;