3-ethynyl-5-((4-((4-(3-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-N-(2-morpholinoethyl)benzamide

Base Information

Chemical Name:3-ethynyl-5-((4-((4-(3-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-N-(2-morpholinoethyl)benzamide
CAS No.:1573025-04-3
Molecular Formula:C₄₅H₄₃N₉O₄
Molecular Weight:773.894
Hs Code.:

3-ethynyl-5-((4-((4-(3-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-N-(2-morpholinoethyl)benzamide

Synonyms:3-ethynyl-5-((4-((4-(3-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-N-(2-morpholinoethyl)benzamide

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Chemical Property of 3-ethynyl-5-((4-((4-(3-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-N-(2-morpholinoethyl)benzamide

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Technology Process of 3-ethynyl-5-((4-((4-(3-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-N-(2-morpholinoethyl)benzamide

There total 10 articles about 3-ethynyl-5-((4-((4-(3-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-N-(2-morpholinoethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1562518-12-0
3-((4-((4-aminonaphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-5-ethynyl-N-(2-morpholinoethyl)benzamide

: 1573025-36-1
phenyl (3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)carbamate

: 1573025-04-3
3-ethynyl-5-((4-((4-(3-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-N-(2-morpholinoethyl)benzamide

Guidance literature:: With triethylamine; In Isopropyl acetate; at 70 ℃; for 1.5h;

Reference yield:

: 1562518-15-3
tert-butyl (4-((2-((3-ethynyl-5-((2-morpholinoethyl)carbamoyl)-phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate

: 1573025-04-3
3-ethynyl-5-((4-((4-(3-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-N-(2-morpholinoethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: triethylamine / Isopropyl acetate / 1.5 h / 70 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; Isopropyl acetate;

Reference yield:

: 1525616-82-3
3-amino-5-bromo-N-(2-morpholinoethyl)benzamide

: 1573025-04-3
3-ethynyl-5-((4-((4-(3-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-N-(2-morpholinoethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 5 h / 85 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran; ethyl acetate / 1 h

3: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 7 h / 55 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5: triethylamine / Isopropyl acetate / 1.5 h / 70 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; Isopropyl acetate; ethyl acetate; N,N-dimethyl-formamide;