tert-butyl (1S,2R)-2-(5-bromo-4-cyano-2-fluorophenylamino)cyclohexylcarbamate

Base Information

Chemical Name:tert-butyl (1S,2R)-2-(5-bromo-4-cyano-2-fluorophenylamino)cyclohexylcarbamate
CAS No.:1374968-88-3
Molecular Formula:C₁₈H₂₃BrFN₃O₂
Molecular Weight:412.302
Hs Code.:

Synonyms:tert-butyl (1S,2R)-2-(5-bromo-4-cyano-2-fluorophenylamino)cyclohexylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (1S,2R)-2-(5-bromo-4-cyano-2-fluorophenylamino)cyclohexylcarbamate

Chemical Property:

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Technology Process of tert-butyl (1S,2R)-2-(5-bromo-4-cyano-2-fluorophenylamino)cyclohexylcarbamate

There total 1 articles about tert-butyl (1S,2R)-2-(5-bromo-4-cyano-2-fluorophenylamino)cyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64695-82-5
2-bromo-4,5-difluorobenzonitrile

: 365996-30-1
tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate

: 1374968-88-3
tert-butyl (1S,2R)-2-(5-bromo-4-cyano-2-fluorophenylamino)cyclohexylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 100 ℃; for 18h;

Reference yield:

: 4369-55-5
3-phenyl-isoxazol-5-ylamine

: 1374968-88-3
tert-butyl (1S,2R)-2-(5-bromo-4-cyano-2-fluorophenylamino)cyclohexylcarbamate

: 1374970-50-9
tert-butyl (1S,2R)-2-(4-cyano-2-fluoro-5-(3-phenylisoxazol-5-ylamino)phenylamino)cyclohexylcarbamate

Guidance literature:: With sodium phenoxide trihydrate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 170 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1374968-88-3
tert-butyl (1S,2R)-2-(5-bromo-4-cyano-2-fluorophenylamino)cyclohexylcarbamate

: 71134-43-5,52547-00-9
3-methyl-5-aminoisothiazole hydrochloride

: 1374974-70-5
C₂₂H₂₈FN₅O₂S

Guidance literature:: With potassium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 120 ℃; for 18h; Inert atmosphere;