2-[1-[4-[3-(4-chlorophenyl)propoxy]benzoyl]isoquinolin-4-yl]acetic acid

Base Information

Chemical Name:2-[1-[4-[3-(4-chlorophenyl)propoxy]benzoyl]isoquinolin-4-yl]acetic acid
CAS No.:1233248-18-4
Molecular Formula:C₂₇H₂₂ClNO₄
Molecular Weight:459.929
Hs Code.:

Synonyms:2-[1-[4-[3-(4-chlorophenyl)propoxy]benzoyl]isoquinolin-4-yl]acetic acid

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Chemical Property of 2-[1-[4-[3-(4-chlorophenyl)propoxy]benzoyl]isoquinolin-4-yl]acetic acid

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Technology Process of 2-[1-[4-[3-(4-chlorophenyl)propoxy]benzoyl]isoquinolin-4-yl]acetic acid

There total 10 articles about 2-[1-[4-[3-(4-chlorophenyl)propoxy]benzoyl]isoquinolin-4-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₂₄ClNO₄

: 1233248-18-4
2-[1-[4-[3-(4-chlorophenyl)propoxy]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2013.10.025

Reference yield:

: 37497-86-2
1-chloro-isoquinoline-4-carboxylic acid methyl ester

: 1233248-18-4
2-[1-[4-[3-(4-chlorophenyl)propoxy]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

1.2: 19.5 h / 20 °C

2.1: sodium hydroxide / methanol / 18 h / 20 - 35 °C

3.1: oxalyl dichloride / chloroform / 3.5 h / 0 - 20 °C

4.1: tetrahydrofuran; acetonitrile; dichloromethane / 2 h / 0 °C

5.1: water; silver(I) acetate / 1,4-dioxane / 0.5 h / 60 °C

6.1: methanol; dichloromethane / 0.5 h / 20 °C

7.1: boron tribromide / chloroform / 2 h / 0 °C

8.1: tributylphosphine; diamide / tetrahydrofuran / 20 °C

9.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

With oxalyl dichloride; tributylphosphine; diamide; water; silver(I) acetate; sodium hexamethyldisilazane; boron tribromide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; acetonitrile; 5.1: |Wolff Rearrangement;
DOI:10.1016/j.bmc.2013.10.025

Reference yield:

: 1233249-52-9
methyl 1-[(4-methoxyphenyl)carbonyl]isoquinoline-4-carboxylate

: 1233248-18-4
2-[1-[4-[3-(4-chlorophenyl)propoxy]benzoyl]isoquinolin-4-yl]acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydroxide / methanol / 18 h / 20 - 35 °C

2: oxalyl dichloride / chloroform / 3.5 h / 0 - 20 °C

3: tetrahydrofuran; acetonitrile; dichloromethane / 2 h / 0 °C

4: water; silver(I) acetate / 1,4-dioxane / 0.5 h / 60 °C

5: methanol; dichloromethane / 0.5 h / 20 °C

6: boron tribromide / chloroform / 2 h / 0 °C

7: tributylphosphine; diamide / tetrahydrofuran / 20 °C

8: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

With oxalyl dichloride; tributylphosphine; diamide; water; silver(I) acetate; boron tribromide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; acetonitrile; 4: |Wolff Rearrangement;
DOI:10.1016/j.bmc.2013.10.025