(2-Fluoro-phenyl)-(1-methyl-1,2,3,4-tetrahydro-quinoxalin-5-yl)-methanone

Base Information

Chemical Name:(2-Fluoro-phenyl)-(1-methyl-1,2,3,4-tetrahydro-quinoxalin-5-yl)-methanone
CAS No.:141875-24-3
Molecular Formula:C₁₆H₁₅FN₂O
Molecular Weight:270.306
Hs Code.:

Synonyms:(2-Fluoro-phenyl)-(1-methyl-1,2,3,4-tetrahydro-quinoxalin-5-yl)-methanone

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Chemical Property of (2-Fluoro-phenyl)-(1-methyl-1,2,3,4-tetrahydro-quinoxalin-5-yl)-methanone

Chemical Property:

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Technology Process of (2-Fluoro-phenyl)-(1-methyl-1,2,3,4-tetrahydro-quinoxalin-5-yl)-methanone

There total 1 articles about (2-Fluoro-phenyl)-(1-methyl-1,2,3,4-tetrahydro-quinoxalin-5-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 36438-97-8
1-methyl-1,2,3,4-tetrahydroquinoxaline

: 394-47-8
2-fluorobenzonitrile

: 141875-24-3
(2-Fluoro-phenyl)-(1-methyl-1,2,3,4-tetrahydro-quinoxalin-5-yl)-methanone

Guidance literature:: With hydrogenchloride; aluminium trichloride; boron trichloride; Yield given. Multistep reaction; 1.) toluene, reflux, 16 h, 2.) toluene, reflux, 2.5 h;
DOI:10.1248/cpb.42.2071

Reference yield: 98.9%

: 598-21-0
2-Bromoacetyl bromide

: 141875-24-3
(2-Fluoro-phenyl)-(1-methyl-1,2,3,4-tetrahydro-quinoxalin-5-yl)-methanone

: 141875-25-4
2-Bromo-1-[8-(2-fluoro-benzoyl)-4-methyl-3,4-dihydro-2H-quinoxalin-1-yl]-ethanone

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1248/cpb.42.2071

Reference yield:

: 141875-24-3
(2-Fluoro-phenyl)-(1-methyl-1,2,3,4-tetrahydro-quinoxalin-5-yl)-methanone

: 141875-26-5
7-(2-Fluoro-phenyl)-3-methyl-8-oxy-2,3-dihydro-1H,9H-3,8,10a-triaza-cyclohepta[de]naphthalen-10-one

Guidance literature:: Multi-step reaction with 2 steps

1: 98.9 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

2: 52.2 percent / 50percent aq. NaOH, NH₂OH*HCl / ethanol / 2.5 h / 50 - 55 °C

With pyridine; sodium hydroxide; hydroxylamine hydrochloride; In ethanol; dichloromethane;
DOI:10.1248/cpb.42.2071