4'-[1-(5-flouro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-6-aza-spiro[2.5]oct-1-yl]-biphenyl-3-carbonitrile

Base Information

Chemical Name:4'-[1-(5-flouro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-6-aza-spiro[2.5]oct-1-yl]-biphenyl-3-carbonitrile
CAS No.:846049-13-6
Molecular Formula:C₂₈H₂₂F₄N₄
Molecular Weight:490.503
Hs Code.:

Synonyms:4'-[1-(5-flouro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-6-aza-spiro[2.5]oct-1-yl]-biphenyl-3-carbonitrile

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Chemical Property of 4'-[1-(5-flouro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-6-aza-spiro[2.5]oct-1-yl]-biphenyl-3-carbonitrile

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Technology Process of 4'-[1-(5-flouro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-6-aza-spiro[2.5]oct-1-yl]-biphenyl-3-carbonitrile

There total 5 articles about 4'-[1-(5-flouro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-6-aza-spiro[2.5]oct-1-yl]-biphenyl-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 846049-12-5
1-(3'-cyano-biphenyl-4-yl)-1-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-6-aza-spiro[2.5]octane-6-carboxylic acid tert-butyl ester

: 846049-13-6
4'-[1-(5-flouro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-6-aza-spiro[2.5]oct-1-yl]-biphenyl-3-carbonitrile

Guidance literature:: With hydrogenchloride; In diethyl ether;
DOI:10.1016/j.bmcl.2006.04.062

Reference yield:

: 846049-67-0
1-(4-bromo-phenyl)-1-formyl-6-aza-spiro[2.5]octane-6-carboxylic acid tert-butyl ester

: 846049-13-6
4'-[1-(5-flouro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-6-aza-spiro[2.5]oct-1-yl]-biphenyl-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / aq. NaHSO₃ / ethanol

2: Pd(PPh₃)4; aq. Na₂CO₃ / toluene; methanol / 0.3 h / 110 °C / microwave irradiation

3: 87 percent / HCl / diethyl ether

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; sodium hydrogensulfite; In methanol; diethyl ether; ethanol; toluene; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.04.062

Reference yield:

: 846049-72-7
1-(4-bromo-phenyl)-1-cyano-6-aza-spiro[2.5]octane-6-carboxylic acid tert-butyl ester

: 846049-13-6
4'-[1-(5-flouro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-6-aza-spiro[2.5]oct-1-yl]-biphenyl-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 27 percent / DIBAL / CH₂Cl₂ / -78 °C

2: 94 percent / aq. NaHSO₃ / ethanol

3: Pd(PPh₃)4; aq. Na₂CO₃ / toluene; methanol / 0.3 h / 110 °C / microwave irradiation

4: 87 percent / HCl / diethyl ether

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisobutylaluminium hydride; sodium carbonate; sodium hydrogensulfite; In methanol; diethyl ether; ethanol; dichloromethane; toluene; 3: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.04.062