5-(2-ethoxybenzo[b]thiophen-3-yl)-4-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazole

Base Information

• Chemical Name: 5-(2-ethoxybenzo[b]thiophen-3-yl)-4-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazole
• CAS No.: 1403580-38-0
• Molecular Formula: C₂₈H₂₁NOS₃
• Molecular Weight: 483.679

Synonyms:5-(2-ethoxybenzo[b]thiophen-3-yl)-4-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazole

Chemical Property of 5-(2-ethoxybenzo[b]thiophen-3-yl)-4-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazole

Chemical Property:

Purity/Quality:

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Technology Process of 5-(2-ethoxybenzo[b]thiophen-3-yl)-4-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazole

There total 3 articles about 5-(2-ethoxybenzo[b]thiophen-3-yl)-4-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4,4,5,5-tetramethyl-2-(2-methylbenzo[b]thiophen-3-yl)-1,3,2-dioxaborolane (1174298-60-2) + 4-bromo-5-(2-ethoxybenzo[b]thiophen-3-yl)-2-phenylthiazole (1403580-57-3) → 5-(2-ethoxybenzo[b]thiophen-3-yl)-4-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazole (1403580-38-0)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In 1,4-dioxane; water; at 110 ℃; for 12h; Inert atmosphere;

DOI:10.1002/ejoc.201200465

Reference yield:

2-phenyl-4,5-dibromo-thiazole (105361-77-1) → 5-(2-ethoxybenzo[b]thiophen-3-yl)-4-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazole (1403580-38-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / 1,4-dioxane; water / 20 h / 110 °C / Inert atmosphere

2: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / 1,4-dioxane; water / 12 h / 110 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In 1,4-dioxane; water;

DOI:10.1002/ejoc.201200465

Reference yield:

2-(2-ethoxybenzo[b]thiophen-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1403580-55-1) → 5-(2-ethoxybenzo[b]thiophen-3-yl)-4-(2-methylbenzo[b]thiophen-3-yl)-2-phenylthiazole (1403580-38-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / 1,4-dioxane; water / 20 h / 110 °C / Inert atmosphere

2: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine / 1,4-dioxane; water / 12 h / 110 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In 1,4-dioxane; water;

DOI:10.1002/ejoc.201200465

upstream raw materials:

2-(2-ethoxybenzo[b]thiophen-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-phenyl-4,5-dibromo-thiazole

4,4,5,5-tetramethyl-2-(2-methylbenzo[b]thiophen-3-yl)-1,3,2-dioxaborolane

4-bromo-5-(2-ethoxybenzo[b]thiophen-3-yl)-2-phenylthiazole

Downstream raw materials:

C₂₈H₂₁NOS₃

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