Technology Process of C21H12F5N3O2
There total 6 articles about C21H12F5N3O2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
dimethyl sulfoxide;
at 150 ℃;
for 0.2h;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium cyanoborohydride; acetic acid
2: potassium carbonate / dimethyl sulfoxide / 80 °C
With
sodium cyanoborohydride; potassium carbonate; acetic acid;
In
dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2013.05.037
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid / 0.5 h / 20 °C / Inert atmosphere
1.2: 20 °C / Cooling
2.1: ammonium bicarbonate; triethylamine; HATU / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
3.1: trifluoroacetic acid / 1 h / 20 °C / Inert atmosphere
4.1: potassium carbonate / dimethyl sulfoxide / 0.2 h / 150 °C / Microwave irradiation
With
ammonium bicarbonate; potassium carbonate; triethylamine; HATU; trifluoroacetic acid;
In
acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;