4-[3-(2-methoxy-phenyl)-pyrazolo[1,5-a]pyrimidin-5-yl]-piperazine-1-carboxylic acid isopropyl ester

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Chemical Name:4-[3-(2-methoxy-phenyl)-pyrazolo[1,5-a]pyrimidin-5-yl]-piperazine-1-carboxylic acid isopropyl ester
CAS No.:1454555-26-0
Molecular Formula:C₂₁H₂₅N₅O₃
Molecular Weight:395.461
Hs Code.:

Synonyms:4-[3-(2-methoxy-phenyl)-pyrazolo[1,5-a]pyrimidin-5-yl]-piperazine-1-carboxylic acid isopropyl ester

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Chemical Property of 4-[3-(2-methoxy-phenyl)-pyrazolo[1,5-a]pyrimidin-5-yl]-piperazine-1-carboxylic acid isopropyl ester

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Technology Process of 4-[3-(2-methoxy-phenyl)-pyrazolo[1,5-a]pyrimidin-5-yl]-piperazine-1-carboxylic acid isopropyl ester

There total 4 articles about 4-[3-(2-methoxy-phenyl)-pyrazolo[1,5-a]pyrimidin-5-yl]-piperazine-1-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454558-23-6
4-(3-bromo-pyrazolo[1,5-a]pyrimidin-5-yl)-piperazine-1-carboxylic acid isopropyl ester

: 5720-06-9
2-Methoxyphenylboronic acid

: 1454555-26-0
4-[3-(2-methoxy-phenyl)-pyrazolo[1,5-a]pyrimidin-5-yl]-piperazine-1-carboxylic acid isopropyl ester

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate monohydrate; In 1,2-dimethoxyethane; water; for 17h; Inert atmosphere; Heating;

Reference yield:

: 960613-96-1
3-bromo-5-chloro-pyrazolo[1,5-a]pyrimidine

: 1454555-26-0
4-[3-(2-methoxy-phenyl)-pyrazolo[1,5-a]pyrimidin-5-yl]-piperazine-1-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2 h / Inert atmosphere; Heating

2: N-ethyl-N,N-diisopropylamine / ethyl acetate; toluene / 0 - 20 °C / Inert atmosphere

3: potassium phosphate monohydrate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,2-dimethoxyethane / 17 h / Inert atmosphere; Heating

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate monohydrate; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; water; ethyl acetate; toluene; 3: |Suzuki Coupling;

Reference yield:

: 29274-24-6
5-chloropyrazolo[1,5-a]pyrimidine

: 1454555-26-0
4-[3-(2-methoxy-phenyl)-pyrazolo[1,5-a]pyrimidin-5-yl]-piperazine-1-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium acetate; acetic acid / 20 °C

1.2: 0.83 h / 0 °C

2.1: 2 h / Inert atmosphere; Heating

3.1: N-ethyl-N,N-diisopropylamine / ethyl acetate; toluene / 0 - 20 °C / Inert atmosphere

4.1: potassium phosphate monohydrate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,2-dimethoxyethane / 17 h / Inert atmosphere; Heating

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate monohydrate; sodium acetate; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; water; ethyl acetate; toluene; 4.1: |Suzuki Coupling;