(S)-methyl 2-((S)-2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanamido)propanoate

Base Information

Chemical Name:(S)-methyl 2-((S)-2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanamido)propanoate
CAS No.:1391932-30-1
Molecular Formula:C₂₃H₂₄N₂O₅
Molecular Weight:408.454
Hs Code.:

Synonyms:(S)-methyl 2-((S)-2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanamido)propanoate

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Chemical Property of (S)-methyl 2-((S)-2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanamido)propanoate

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Technology Process of (S)-methyl 2-((S)-2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanamido)propanoate

There total 4 articles about (S)-methyl 2-((S)-2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1354894-23-7
(S)-2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanoic acid

: 2491-20-5
L-alanine methyl ester hydrochloride

: 1391932-30-1
(S)-methyl 2-((S)-2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanamido)propanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 12h; Inert atmosphere;
DOI:10.1002/chem.201103322

Reference yield: 23.0%

: 4-ethynylbenzyl carbonochloridate

: 15136-29-5
(S)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)propanoate

: 1391932-30-1
(S)-methyl 2-((S)-2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanamido)propanoate

Guidance literature:: (S)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)propanoate; With hydrogenchloride; In 1,4-dioxane; dichloromethane; water; at 25 ℃; for 0.5h;

4-ethynylbenzyl carbonochloridate; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.3390/molecules26051227

Reference yield:

: 10602-04-7
(4-ethynylphenyl)methanol

: 1391932-30-1
(S)-methyl 2-((S)-2-((((4-ethynylbenzyl)oxy)carbonyl)amino)-3-phenylpropanamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / methanol / Inert atmosphere

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 25 °C / Inert atmosphere

With thionyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/chem.201103322