*,S^*)>-5-<<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl>amino>-5-oxopentanoic acid

Base Information

• Chemical Name: *,S^*)>-5-<<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl>amino>-5-oxopentanoic acid
• CAS No.: 130406-57-4
• Molecular Formula: C₃₇H₄₆N₄O₆
• Molecular Weight: 642.795

Synonyms:*,S^*)>-5-<<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl>amino>-5-oxopentanoic acid

Chemical Property of *,S^*)>-5-<<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl>amino>-5-oxopentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of *,S^*)>-5-<<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl>amino>-5-oxopentanoic acid

There total 10 articles about *,S^*)>-5-<<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl>amino>-5-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

tricyclo<3.3.1.13,7>dec-2-yl *,S*)>-3-(1H-indol-3-ylmethyl)-3-methyl-4,9,13-trioxo-6-(phenylmethyl)-14-oxa-2,5,8-triazapentadecanoate (130406-54-1) → *,S*)>-5-<<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl>amino>-5-oxopentanoic acid (130406-57-4)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 4.5h;

DOI:10.1021/jm00105a062

Reference yield:

1-adamantanol (700-57-2) → *,S*)>-5-<<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl>amino>-5-oxopentanoic acid (130406-57-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 100 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

2: 89 percent / Et₃N / tetrahydrofuran / 0.25 h

3: 90 percent / LiOH / H₂O; dioxane / 18 h / Ambient temperature

4: 1.) C₆F₅OH, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 18 h, 2.) 48 h

5: 95 percent / AcOH, H₂ / 10percent Pd/C / ethanol / 30 °C / 2585.7 Torr

6: 69 percent / Et₃N / ethyl acetate / 4 h / Ambient temperature

7: 65 percent / 0.1 M aq. LiOH / tetrahydrofuran / 4.5 h / 0 °C

With pyridine; lithium hydroxide; 2,3,4,5,6-pentafluorophenol; hydrogen; acetic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate;

DOI:10.1021/jm00105a062

Reference yield:

(9-fluorenylmethoxycarbonyl)-L-phenylalaninol (129397-83-7) → *,S*)>-5-<<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl>amino>-5-oxopentanoic acid (130406-57-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 80 percent / HN₃, Ph₃P, (i-PrO₂CN)2 / tetrahydrofuran; toluene / 1 h / Ambient temperature

2: 86 percent / LiOH, H₂O / dioxane / 18 h / Ambient temperature

3: 1.) C₆F₅OH, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 18 h, 2.) 48 h

4: 95 percent / AcOH, H₂ / 10percent Pd/C / ethanol / 30 °C / 2585.7 Torr

5: 69 percent / Et₃N / ethyl acetate / 4 h / Ambient temperature

6: 65 percent / 0.1 M aq. LiOH / tetrahydrofuran / 4.5 h / 0 °C

With lithium hydroxide; tris-(2-chloro-ethyl)-amine; di-isopropyl azodicarboxylate; 2,3,4,5,6-pentafluorophenol; water; hydrogen; acetic acid; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; ethyl acetate; toluene;

DOI:10.1021/jm00105a062

upstream raw materials:

tricyclo<3.3.1.1^3,7>dec-2-yl *,S^*)>-3-(1H-indol-3-ylmethyl)-3-methyl-4,9,13-trioxo-6-(phenylmethyl)-14-oxa-2,5,8-triazapentadecanoate

methyl 4-(chlorocarbonyl)butyrate

1-adamantanol

(9-fluorenylmethoxycarbonyl)-L-phenylalaninol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 130406-57-4 *,S^*)>-5-<<2-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-3-phenylpropyl>amino>-5-oxopentanoic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send