1-cyano-N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}cyclopropanecarboxamide

Base Information

Chemical Name:1-cyano-N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}cyclopropanecarboxamide
CAS No.:1318754-93-6
Molecular Formula:C₁₇H₁₄F₃N₃OS
Molecular Weight:365.379
Hs Code.:

Synonyms:1-cyano-N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}cyclopropanecarboxamide

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Chemical Property of 1-cyano-N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}cyclopropanecarboxamide

Chemical Property:

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Technology Process of 1-cyano-N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}cyclopropanecarboxamide

There total 5 articles about 1-cyano-N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1318757-68-4
4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazole-5-amine

: 6914-79-0
1-cyano-cyclopropanecarboxylic acid

: 1318754-93-6
1-cyano-N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}cyclopropanecarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 60 ℃; for 24h;

Reference yield:

: 2338-76-3
3-trifluoromethylphenylacetonitrile

: 1318754-93-6
1-cyano-N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate / ethyl acetate / 20 °C

2.1: pyridine / 7 h / 20 °C

3.1: sodium hydroxide; water / ethanol / 0.5 h / 0 - 20 °C

3.2: ion exchange resin CG₅₀ / 0.5 h / 20 °C

4.1: triethylamine; diphenyl phosphoryl azide / 2 h / 90 °C

5.1: hydrogenchloride / ethanol; water / 0.17 h / 20 °C

5.2: 0 °C / pH 9 - 10

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 24 h / 60 °C

With pyridine; hydrogenchloride; diphenyl phosphoryl azide; water; O,O-Diethyl hydrogen phosphorodithioate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1318757-52-6
tert-butyl {4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}carbamate

: 1318754-93-6
1-cyano-N-{4-methyl-2-[3-(trifluoromethyl)benzyl]-1,3-thiazol-5-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethanol; water / 0.17 h / 20 °C

1.2: 0 °C / pH 9 - 10

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 24 h / 60 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; water; N,N-dimethyl-formamide;