N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)ethenesulfonamide

Base Information

Chemical Name:N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)ethenesulfonamide
CAS No.:1428444-20-5
Molecular Formula:C₁₈H₁₈N₈O₂S
Molecular Weight:410.459
Hs Code.:

Synonyms:N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)ethenesulfonamide

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Chemical Property of N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)ethenesulfonamide

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Technology Process of N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)ethenesulfonamide

There total 4 articles about N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)ethenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23002-51-9
6-chloro-1H-pyrazolo[3,4-d]pyrimidine

: 1428444-20-5
N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)ethenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 20 h / 20 °C

2: hydrogenchloride / isopropyl alcohol; water / 18 h / 90 °C

3: hydrogenchloride; palladium on activated charcoal; hydrogen / water; methanol / 2 h

4: N-ethyl-N,N-diisopropylamine; sodium hydrogencarbonate / dichloromethane / 3.5 h / 20 °C

With hydrogenchloride; palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 1622-32-8
2-Chloroethanesulfonyl chloride

: 1428444-29-4
1-(3-aminobenzyl)-N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine

: 1428444-20-5
N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)ethenesulfonamide

Guidance literature:: With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3.5h;

Reference yield:

: 3958-57-4
1-bromomethyl-3-nitrobenzene

: 1428444-20-5
N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)ethenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 20 h / 20 °C

2: hydrogenchloride / isopropyl alcohol; water / 18 h / 90 °C

3: hydrogenchloride; palladium on activated charcoal; hydrogen / water; methanol / 2 h

4: N-ethyl-N,N-diisopropylamine; sodium hydrogencarbonate / dichloromethane / 3.5 h / 20 °C

With hydrogenchloride; palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water; isopropyl alcohol; acetonitrile;