(1S,4aR,8R,8aS)-8-Ethyl-2-[1-((1S,2R,4R)-2-hydroxy-4-methyl-cyclohexyl)-1-methyl-ethyl]-1-methyl-2,3,4,4a,5,8-hexahydro-1H-isoquinolin-8a-ol

Base Information

• Chemical Name: (1S,4aR,8R,8aS)-8-Ethyl-2-[1-((1S,2R,4R)-2-hydroxy-4-methyl-cyclohexyl)-1-methyl-ethyl]-1-methyl-2,3,4,4a,5,8-hexahydro-1H-isoquinolin-8a-ol
• CAS No.: 217457-80-2
• Molecular Formula: C₂₂H₃₉NO₂
• Molecular Weight: 349.557

Synonyms:(1S,4aR,8R,8aS)-8-Ethyl-2-[1-((1S,2R,4R)-2-hydroxy-4-methyl-cyclohexyl)-1-methyl-ethyl]-1-methyl-2,3,4,4a,5,8-hexahydro-1H-isoquinolin-8a-ol

Chemical Property of (1S,4aR,8R,8aS)-8-Ethyl-2-[1-((1S,2R,4R)-2-hydroxy-4-methyl-cyclohexyl)-1-methyl-ethyl]-1-methyl-2,3,4,4a,5,8-hexahydro-1H-isoquinolin-8a-ol

Chemical Property:

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Technology Process of (1S,4aR,8R,8aS)-8-Ethyl-2-[1-((1S,2R,4R)-2-hydroxy-4-methyl-cyclohexyl)-1-methyl-ethyl]-1-methyl-2,3,4,4a,5,8-hexahydro-1H-isoquinolin-8a-ol

There total 2 articles about (1S,4aR,8R,8aS)-8-Ethyl-2-[1-((1S,2R,4R)-2-hydroxy-4-methyl-cyclohexyl)-1-methyl-ethyl]-1-methyl-2,3,4,4a,5,8-hexahydro-1H-isoquinolin-8a-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H29NO2 (217457-59-5) → (1S,4aR,8R,8aS)-8-Ethyl-2-[1-((1S,2R,4R)-2-hydroxy-4-methyl-cyclohexyl)-1-methyl-ethyl]-1-methyl-2,3,4,4a,5,8-hexahydro-1H-isoquinolin-8a-ol (217457-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / toluene / 0.25 h / Ambient temperature

2: toluene / 20 h / Ambient temperature

In toluene;

DOI:10.1021/jo981075c

Reference yield:

triethylaluminum (97-93-8) + (1R,2S,5R)-5-Methyl-2-[1-methyl-1-((1S,2S,6S,8R)-2-methyl-11-oxa-3-aza-tricyclo[6.2.1.01,6]undec-9-en-3-yl)-ethyl]-cyclohexanol (217457-76-6) → (1S,4aR,8R,8aS)-8-Ethyl-2-[1-((1S,2R,4R)-2-hydroxy-4-methyl-cyclohexyl)-1-methyl-ethyl]-1-methyl-2,3,4,4a,5,8-hexahydro-1H-isoquinolin-8a-ol (217457-80-2) + (1S,4aS,6R,7S)-7-Ethyl-2-[1-((1S,2R,4R)-2-hydroxy-4-methyl-cyclohexyl)-1-methyl-ethyl]-1-methyl-1,2,3,4,4a,5,6,7-octahydro-isoquinolin-6-ol

Guidance literature:

In toluene; for 20h; Yield given; Yields of byproduct given; Ambient temperature;

DOI:10.1021/jo981075c

Reference yield: 98.0%

(1S,4aR,8R,8aS)-8-Ethyl-2-[1-((1S,2R,4R)-2-hydroxy-4-methyl-cyclohexyl)-1-methyl-ethyl]-1-methyl-2,3,4,4a,5,8-hexahydro-1H-isoquinolin-8a-ol (217457-80-2) → (1S,4aR,8R,8aR)-8-Ethyl-2-[1-((1S,2R,4R)-2-hydroxy-4-methyl-cyclohexyl)-1-methyl-ethyl]-1-methyl-octahydro-isoquinolin-8a-ol (217457-84-6)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; for 24h; Ambient temperature;

DOI:10.1021/jo981075c

upstream raw materials:

triethylaluminum

(1R,2S,5R)-5-Methyl-2-[1-methyl-1-((1S,2S,6S,8R)-2-methyl-11-oxa-3-aza-tricyclo[6.2.1.0^1,6]undec-9-en-3-yl)-ethyl]-cyclohexanol

C₁₉H₂₉NO₂

Downstream raw materials:

(1S,4aR,8R,8aR)-8-Ethyl-2-[1-((1S,2R,4R)-2-hydroxy-4-methyl-cyclohexyl)-1-methyl-ethyl]-1-methyl-octahydro-isoquinolin-8a-ol

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