(S)-(-)-1-(tert-butoxycarbonyl)-3-[(tert-butyldiphenylsilyl)oxy]pyrrolidin-2-one

Base Information

Chemical Name:(S)-(-)-1-(tert-butoxycarbonyl)-3-[(tert-butyldiphenylsilyl)oxy]pyrrolidin-2-one
CAS No.:259264-59-0
Molecular Formula:C₂₅H₃₃NO₄Si
Molecular Weight:439.627
Hs Code.:

Synonyms:(S)-(-)-1-(tert-butoxycarbonyl)-3-[(tert-butyldiphenylsilyl)oxy]pyrrolidin-2-one

Suppliers and Price of (S)-(-)-1-(tert-butoxycarbonyl)-3-[(tert-butyldiphenylsilyl)oxy]pyrrolidin-2-one

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Chemical Property of (S)-(-)-1-(tert-butoxycarbonyl)-3-[(tert-butyldiphenylsilyl)oxy]pyrrolidin-2-one

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Technology Process of (S)-(-)-1-(tert-butoxycarbonyl)-3-[(tert-butyldiphenylsilyl)oxy]pyrrolidin-2-one

There total 1 articles about (S)-(-)-1-(tert-butoxycarbonyl)-3-[(tert-butyldiphenylsilyl)oxy]pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 259264-58-9
(S)-(-)-3-[(tert-butyldiphenylsilyl)oxy]pyrrolidin-2-one

: 259264-59-0
(S)-(-)-1-(tert-butoxycarbonyl)-3-[(tert-butyldiphenylsilyl)oxy]pyrrolidin-2-one

Guidance literature:: With triethylamine; dmap; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/ja993295t

Reference yield: 94.0%

: 259264-59-0
(S)-(-)-1-(tert-butoxycarbonyl)-3-[(tert-butyldiphenylsilyl)oxy]pyrrolidin-2-one

: 259264-60-3
(3S)-1-(tert-butoxycarbonyl)-3-[(tert-butyldiphenylsilyl)oxy]-2-hydroxypyrrolidine

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.5h;
DOI:10.1021/ja993295t

Reference yield:

: 259264-59-0
(S)-(-)-1-(tert-butoxycarbonyl)-3-[(tert-butyldiphenylsilyl)oxy]pyrrolidin-2-one

: 5-phenyl-2,3-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / NaBH₄ / methanol / 0.5 h / 0 °C

2: 62 percent / montmorillonite K₁₀ clay; 4 Angstroem molecular sieves / CH₂Cl₂ / 12 h / 20 °C

3: n-BuLi / tetrahydrofuran; hexane / 1.25 h / -78 - 0 °C

With sodium tetrahydroborate; n-butyllithium; 4 A molecular sieve; Montmorillonite K₁₀ clay; In tetrahydrofuran; methanol; hexane; dichloromethane; 1: Reduction / 2: Alkylation / 3: Elimination;
DOI:10.1021/ja993295t