{(1R,2R,3R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(R)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propyl]-1,3-dimethyl-pent-4-enyloxymethyl}-benzene

Base Information

• Chemical Name: {(1R,2R,3R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(R)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propyl]-1,3-dimethyl-pent-4-enyloxymethyl}-benzene
• CAS No.: 123618-89-3
• Molecular Formula: C₃₀H₅₆O₃Si₂
• Molecular Weight: 520.944
• Mol file: 123618-89-3.mol

Synonyms:{(1R,2R,3R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(R)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propyl]-1,3-dimethyl-pent-4-enyloxymethyl}-benzene

Chemical Property of {(1R,2R,3R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(R)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propyl]-1,3-dimethyl-pent-4-enyloxymethyl}-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(1R,2R,3R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(R)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propyl]-1,3-dimethyl-pent-4-enyloxymethyl}-benzene

There total 12 articles about {(1R,2R,3R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(R)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propyl]-1,3-dimethyl-pent-4-enyloxymethyl}-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,4R)-2-benzyloxy-5-tert-butyldimethylsiloxy-2,4-dimethylpentanal (114114-18-0) → {(1R,2R,3R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(R)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propyl]-1,3-dimethyl-pent-4-enyloxymethyl}-benzene (123618-89-3)

Guidance literature:

Multi-step reaction with 2 steps

1: MgBr₂ / CH₂Cl₂ / 20 °C

2: Et₃N / CH₂Cl₂

With triethylamine; magnesium bromide; In dichloromethane;

DOI:10.1016/S0040-4039(00)96400-1

Reference yield:

(2R,4R)-4-Benzyloxy-2,4-dimethyl-hex-5-enal (114114-16-8) → {(1R,2R,3R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(R)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propyl]-1,3-dimethyl-pent-4-enyloxymethyl}-benzene (123618-89-3)

Guidance literature:

Multi-step reaction with 5 steps

1: LiAlH₄ / diethyl ether

2: ImH / dimethylformamide

3: 85 percent / O₃ / CH₂Cl₂; pyridine

4: MgBr₂ / CH₂Cl₂ / 20 °C

5: Et₃N / CH₂Cl₂

With 1H-imidazole; lithium aluminium tetrahydride; ozone; triethylamine; magnesium bromide; In pyridine; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)96400-1

Reference yield:

(3R,5R)-3-benzyloxy-6-tert-butyldimethylsiloxy-3,5-dimethylhex-1-ene (114114-17-9) → {(1R,2R,3R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(R)-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-propyl]-1,3-dimethyl-pent-4-enyloxymethyl}-benzene (123618-89-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / O₃ / CH₂Cl₂; pyridine

2: MgBr₂ / CH₂Cl₂ / 20 °C

3: Et₃N / CH₂Cl₂

With ozone; triethylamine; magnesium bromide; In pyridine; dichloromethane;

DOI:10.1016/S0040-4039(00)96400-1

upstream raw materials:

t-butyldimethylsiyl triflate

(3S,4R,5R,7R)-5-Benzyloxy-8-(tert-butyl-dimethyl-silanyloxy)-3,5,7-trimethyl-oct-1-en-4-ol

(2R,4R)-4-Benzyloxy-2,4-dimethyl-hex-5-enal

1,6-anhydro-2,3-didesoxy-2,4-di-C-methyl-4-O-benzyl-β-D-galactopyranose

Downstream raw materials:

(2R,4R,5R,6R)-4-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-oct-7-en-1-ol

(2R,3R,4R,6R)-4-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4,6-trimethyl-heptanal

(2R,3R,5R,6R)-3-Benzyloxy-6-methoxy-3,5-dimethyl-2-((R)-1-methyl-allyl)-tetrahydro-pyran

(2R,3R,5R,6S)-3-Benzyloxy-6-methoxy-3,5-dimethyl-2-((R)-1-methyl-allyl)-tetrahydro-pyran